Results 61 to 70 of about 24,216,023 (259)

Bayesian hierarchical clustering for studying cancer gene expression data with unknown statistics [PDF]

, 2013
Clustering analysis is an important tool in studying gene expression data. The Bayesian hierarchical clustering (BHC) algorithm can automatically infer the number of clusters and uses Bayesian model selection to improve clustering quality. In this paper,
Muhammad F Bari, Bari Muhammad F., Sirinukunwattana Korsuk, Bari, Muhammad F., Muhammad F. Bari, Savage, Richard S., David R. J. Snead, David R. J. Snead (475600), Richard S Savage, Richard S. Savage, Rajpoot Nasir M., Muhammad F. Bari (417733), Snead, David R. J., David R J Snead, Richard S. Savage (341629), Nasir M. Rajpoot, Korsuk Sirinukunwattana (475599), Rajpoot, Nasir M., Sirinukunwattana, Korsuk, Korsuk Sirinukunwattana, Snead, David R.J., Snead David R. J., Nasir M. Rajpoot (185555), Nasir M Rajpoot, Savage Richard S.   +24 more
core   +2 more sources

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

DBSCAN Clustering Algorithms for Non-Uniform Density Data and Its Application in Urban Rail Passenger Aggregation Distribution

Energies, 2019
With the emergence of all kinds of location services applications, massive location data are collected in real time. A hierarchical fast density clustering algorithm, DBSCAN(density based spatial clustering of applications with noise) algorithm based on ...
Xiaolu Li, Peng Zhang, Guangyu Zhu
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Agroecological Practices on Private Farms in the Province of Camagüey, Cuba.

Revista de Producción Animal, 2017
The aim of this research was to gather together the dairy farms of the José Antonio Echeverría Strengthened Coop-erative of Credits and Services (CCSF) in the province of Camaguey, Cuba, according to the frequency of application or no application of ...
Yorkis Tamayo Escobar , Miriel Cabrera Núñez , Servando Soto Senra , Noemí Fernández Pérez , Florentino Uña Izquierdo , Roberto Vásquez Montes de Oca   +5 more
doaj  

Insurance Analytics with Clustering Techniques

Risks
The K-means algorithm and its variants are well-known clustering techniques. In actuarial applications, these partitioning methods can identify clusters of policies with similar attributes.
Charlotte Jamotton, Donatien Hainaut, Thomas Hames   +2 more
doaj   +1 more source