Results 231 to 240 of about 843,626 (294)

Engineering Compact Base Editors by AlphaFold‐Guided Mutation Scan and Escherichia coli‐Based Tri‐Selection

Advanced Science, EarlyView.
A miniaturized deaminase SsdAtox was scanned with AlphaFold to identify DNA binding pocket hot spots. Site‐saturation mutagenesis at gatekeeper residue K31 yielded ten‐fold activity enhancement. Trinity Screen, an E. coli‐based three‐in‐one platform selecting for high activity and reduced double‐strand breaks, enabled combinatorial evolution at DNA ...
Ryeo Gang Son, Goeun Kim, Jungjoon K. Lee   +2 more
wiley   +1 more source

PET-TURTLE: Deep Unsupervised Support Vector Machines for Imbalanced Data Clusters. [PDF]

IEEE Signal Process Lett
Salazar Cavazos J.
europepmc   +1 more source

Radical‐Mediated, Substrate‐Independent Fabrication of Hybrid Solid–Hydrogel Materials With Tunable Crosslinking: An Initiator‐ and Crosslinker‐Free Approach

Advanced Science, EarlyView.
This work introduces a substrate‐independent, reagent‐free plasma strategy that forms radical‐rich interlayers for covalent hydrogel attachment without initiators or crosslinkers. The long‐lived radicals drive in situ gelation, creating robust, cytocompatible hybrid solid–hydrogel constructs across diverse substrates.
Ghazal Shineh, Azin Khodaei, Pardis Keikhosravani, Masoud Zhianmanesh, Yiyun Xia, Aaron Gilmour, Sina Naficy, Andrea Guzina, Daniella Bianchi, Khoon S. Lim, Fariba Dehghani, Saber Amin Yavari, Marcela Bilek, Giselle C. Yeo, Behnam Akhavan   +14 more
wiley   +1 more source

MCS Assisted Accurate Perception Framework for Urban POI Classification. [PDF]

Sensors (Basel)
Feng X, Yang Y, Zhang X, Guo D, Yang G.
europepmc   +1 more source

Calcium Channel Blockers Inhibit Pancreatic Neuroendocrine Neoplasms Progression via Cav1.2‐Epigenetic Circuit

Advanced Science, EarlyView.
Our study reveals a novel mechanism of a positive regulatory circuit between Cav1.2 and H3K27ac for pancreatic neuroendocrine neoplasms (pNENs) progression. Cav1.2 is identified as a crucial target for promoting disease progression and correlates with malignant behaviors, which are remarkably inhibited by the administration of calcium channel blockers (
Yangyinhui Yu, Qiongcong Xu, Jinzhao Xie, Mingjian Ma, Xitai Huang, Yinhao Shi, Jiawei Zhou, Enliang Zhu, Ziyi Zhao, Ning Zhang, Zhide Liu, Jingyuan Ye, Xiaoyu Yin   +12 more
wiley   +1 more source

Gene expression data mining by hybrid biclustering with improved GA and BA. [PDF]

Sci Rep
Wu Z, Wang J, Wang X.
europepmc   +1 more source

Energy-efficient wireless sensor network for urban groundwater level monitoring using machine learning and sink mobility. [PDF]

Sci Rep
Manchanda R, Lakshmi AV, Kaur G, Sudhamsu G, Samal SK, Jebaselvi GDA, Kumar R, Bhowmik A, Ashok N.   +8 more
europepmc   +1 more source

An energy aware cluster inspired routing protocol using multi strategy improved crayfish optimization algorithm for guaranteeing green communication in IoT. [PDF]

Sci Rep
Chithra R, Sarumathiy CK, Padma E, Arulkumar R.   +3 more
europepmc   +1 more source

The Priming Effect of Auxiliary Line Construction on Mathematical Creative Thinking: An fNIRS Study. [PDF]

J Intell
Zhang C, An K, Li J, Yang Q, Song M, Wang L.   +5 more
europepmc   +1 more source