Results 211 to 220 of about 3,770,727 (360)

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Material and immaterial dimensions of clusters. Cooperation and learning as infrastructure for innovation [PDF]

The paper concentrates on forms of cooperation in a learning context and presents theory-based empirical results of interactive learning processes in different clusters.
Hartmann, Christian, Steiner, Michael
core  

FeSseqdb: a curated sequence-level database and interpretable machine learning framework for identifying iron-sulfur proteins. [PDF]

BMC Bioinformatics
Min J, Brooks BR, Amin M.
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

scMagnifier: Resolving fine-grained cell subtypes via GRN-informed perturbations and consensus clustering. [PDF]

PLoS Comput Biol
He Z, Dong K.
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Unsupervised clustering of PET/CT features in fever of unknown origin (FUO) and inflammation of unknown origin (IUO). [PDF]

Front Med (Lausanne)
Ceylan S, Ceylan B, Olmuscelik O, Cakir T.   +3 more
europepmc   +1 more source

Galaxy morphology in rich clusters: Implications for the formation and evolution of galaxies

, 1980
A. Dressler
semanticscholar   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Regional Food Clusters and Government Support for Clustering: Evidence for a ‘Dynamic Food Innovation Cluster’ in Alberta, Canada?

This paper analyzes government support for networking and regional cluster growth in the food sector. It is, to the best of our knowledge, the first paper to provide a literature review of studies on regional food clusters, focusing on key features that ...
Ali, Jolene, Steiner, Bodo E.
core