Results 91 to 100 of about 2,841,488 (326)

Improved step size adaptation for the MO-CMA-ES [PDF]

Proceedings of the 12th annual conference on Genetic and evolutionary computation, 2010
The multi-objective covariance matrix adaptation evolution strategy (MO-CMA-ES) is an evolutionary algorithm for continuous vector-valued optimization. It combines indicator- based selection based on the contributing hypervolume with the efficient strategy parameter adaptation of the elitist covariance matrix adaptation evolution strategy (CMA-ES ...
Voss, Thomas, Hansen, Nikolaus, Igel, Christian   +2 more
openaire   +2 more sources

KL-based Control of the Learning Schedule for Surrogate Black-Box Optimization [PDF]

, 2013
This paper investigates the control of an ML component within the Covariance Matrix Adaptation Evolution Strategy (CMA-ES) devoted to black-box optimization.
Loshchilov, Ilya, Schoenauer, Marc, Sebag, Michèle   +2 more
core   +3 more sources

Dual Covalent Targeting of STING Cysteines 292/309 Disrupts Functional Oligomerization and Enables Potent Antagonist Development

Advanced Science, EarlyView.
We report a rational design strategy for STING antagonists by dual covalent targeting of Cys292/309 in its C‐terminal domain, directly preventing functional oligomerization. Through covalent warhead repurposing, we identified P005091 and revealed its unique dual‐cysteine mechanism.
Yuxuan Zhao, Ling Huang, Wenjing Qin, Bin Zhang, Yang Yang, Xue Chen, Xiaoquan Wang, Weilin Zhou, Feiyang Chen, Zhenyu Li, Liyuan Le, Yiqiu Zhang, Zhen Xiang, Lu Zhang, Fei Wang, Dan Lei, Zi‐zhe Cai, Ying Gao, Yong Chen, Xuecen Wang, Junmin Quan, Shuixing Zhang, Xianzhang Bu, Xin Yue   +23 more
wiley   +1 more source

Massively Parallel CMA‐ES With Increasing Population

Concurrency and Computation: Practice and Experience
ABSTRACT The Increasing Population Covariance Matrix Adaptation Evolution Strategy (IPOP‐CMA‐ES) algorithm is a reference stochastic optimizer dedicated to blackbox optimization, where no prior knowledge about the underlying problem structure is available.
Redon, David, Fortin, Pierre, Derbel, Bilel, Tsuji, Miwako, Sato, Mitsuhisa   +4 more
openaire   +2 more sources

Accelerating evolutionary algorithms by means of Gaussian processes [PDF]

, 2015
Tato práce zkoumá výkon gaussovských procesů (GP) v souvislosti s metodou zvanou Covariance Matrix Adaptation Evolution Strategy (CMA-ES), state-of-the-art v oblasti evoluční optimalizace.
Kudinov Andrej
core  

Covalent Reprogramming of Kinase Binders to Modulate Protein Abundance

Advanced Science, EarlyView.
Electrophilic remodeling of a broad‐spectrum kinase binder reveals how subtle chemical changes reprogram protein fate. An acrylamide analog of a multi‐kinase binder selectively stabilizes Aurora kinase A (AURKA) by suppressing its ubiquitination, while a short‐linker variant converts this stabilizer into a degrader.
Chen Mozes, Xiaokang Jin, Miguel A. Campos, Chen Zhou, Xiaoyu Zhang   +4 more
wiley   +1 more source

Development of an efficient system for predicting CRSS ratios of HCP polycrystalline metals using uniaxial loading conditions

Nihon Kikai Gakkai ronbunshu
Critical resolved shear stress (CRSS) is one of the most important parameters in the field of plasticity in metals, and the CRSS ratios between slip systems govern the plastic anisotropy, workability, and so on.
Sotaro MIKAMI, Yoshiki KAWANO, Kenji IWADATE   +2 more
doaj   +1 more source

Mapping the Innovation DNA of Agribusiness Firms: A Multi‐Method Analysis of Strategic Capabilities and Performance

Agribusiness, EarlyView.
ABSTRACT Innovation is essential for competitiveness in agribusiness facing dynamic environments. This study examines how market orientation, marketing, relational, and social capabilities influence innovation performance. Using data from 751 Spanish firms and a multi‐method approach that integrates Structural Equation Modeling (PLS‐SEM), Necessary ...
Beatriz Corchuelo Martínez‐Azúa, Alvaro Dias   +1 more
wiley   +1 more source

Solving satisfiability in fuzzy logics by mixing CMA-ES [PDF]

Proceedings of the 15th annual conference on Genetic and evolutionary computation, 2013
Satisfiability in propositional logic is well researched and many approaches to checking and solving exist. In infinite-valued or fuzzy logics, however, there have only recently been attempts at developing methods for solving satisfiability. In this paper, we propose new benchmark problems and analyse the function landscape of different problem classes,
Brys, Tim, Drugan, Madalina, Bosman, Peter A.n., De Cock, Martine, Nowe, Ann   +4 more
openaire   +3 more sources

Advanced Experiment Design Strategies for Drug Development

Advanced Intelligent Discovery, EarlyView.
Wang et al. analyze 592 drug development studies published between 2020 and 2024 that applied design of experiments methodologies. The review surveys both classical and emerging approaches—including Bayesian optimization and active learning—and identifies a critical gap between advanced experimental strategies and their practical adoption in ...
Fanjin Wang, Anthony Harker, Mohan Edirisinghe, Maryam Parhizkar   +3 more
wiley   +1 more source