Results 81 to 90 of about 2,841,488 (326)
An Evolutional Topology Optimization Method Based on Kernel Level Set Function
IEEE AccessTopology optimizations involving evolutionary algorithms are promising approaches to solve practical engineering design problems, since their use of derivation-free algorithms makes them applicable to any design problem.
Takahiro Sato +2 more
doaj +1 more source
IEEE Access, 2023 Uncertainties caused by material variation can significantly impair the characteristics of devices. Therefore, it is important to design devices whose performance is not significantly damaged even when material variations occur. Robust optimization seeks
Akito Maruo, Hajime Igarashi
doaj +1 more source
Advanced Healthcare Materials, EarlyView.A tunable bifunctional surface is developed by combining Fc‐binding peptides and RGD motifs to present oriented antibodies alongside integrin‐mediated signaling. The platform selectively captures endothelial colony‐forming cells while promoting their adhesion and proliferation.
Hugo A. Level +5 more
wiley +1 more source
Large-Scale Evolutionary Strategy Based on Gradient Approximation
Complexity, 2021 For large-scale optimization, CMA-ES has the disadvantages of high complexity and premature stagnation. An improved CMA-ES algorithm called GI-ES was proposed in this paper.
Jin Jin
doaj +1 more source
Advanced Science, EarlyView.Nuclear metabolism oscillates during cell cycle progression. Quantitative chromatome proteomics and imaging reveal phase‐specific dynamics of PIP5K1A and nuclear PIP2, linking phosphatidylinositol metabolism to histone methylation. This work identifies nuclear lipid metabolism as a previously unrecognized regulatory axis coordinating chromatin ...
Antoni Gañez‐Zapater +13 more
wiley +1 more source
On the Effect of Mirroring in the IPOP Active CMA-ES on the Noiseless BBOB Testbed [PDF]
, 2012 International audienceMirrored mutations and active covariance matrix adaptation are two recent ideas to improve the well-known covariance matrix adaptation evolution strategy (CMA-ES)---a state-of-the-art algorithm for numerical optimization.
Auger, Anne +2 more
core +3 more sources
Improved Systemic Immunochemotherapy Employing an Oxaliplatin‐TLR7/8 Agonist Prodrug Strategy
Advanced Science, EarlyView.A platinum(IV) prodrug is developed to systemically deliver the TLR7/8 agonist gardiquimod. Tumor‐targeting is mediated by an albumin‐binding maleimide, which limits premature complex activation. Ox‐Gardi‐Mal accumulates specifically in the tumor, where it activates the immune system.
Michael Gutmann +15 more
wiley +1 more source
Advanced Science, EarlyView.In the present study, we have demonstrated that the NUP85‐USP47‐ASK1 signaling pathway may have regulated the progression of liver fibrosis through modulating ERS. Additionally, we have developed a CREKA‐coupled liposome to target delivery of MV, a pharmacological inhibitor of NUP85, to activated HSCs, thereby attenuating liver fibrosis. ABSTRACT Liver
Dashuai Yang +11 more
wiley +1 more source
A CMA-ES-Based Adversarial Attack on Black-Box Deep Neural Networks
IEEE Access, 2019 Deep neural networks(DNNs) are widely used in AI-controlled Cyber-Physical Systems (CPS) to controll cars, robotics, water treatment plants and railways.
Xiaohui Kuang +5 more
doaj +1 more source