Results 101 to 110 of about 36,566 (221)
Novel network pharmacology methods for drug mechanism of action identification, pre-clinical drug screening and drug repositioning [PDF]
, 2011 The high rates of failure in oncology drug clinical trials highlight the problems of using pre-clinical data to predict the clinical effects of drugs. Here we present two methodology innovations on network pharmacology modeling.
Jianghui Xiong
core +1 more source
Optimal Portfolio Choice With Cross‐Impact Propagators
Mathematical Finance, EarlyView.ABSTRACT We consider a class of optimal portfolio choice problems in continuous time where the agent's transactions create both transient cross‐impact driven by a matrix‐valued Volterra propagator, as well as temporary price impact. We formulate this problem as the maximization of a revenue‐risk functional, where the agent also exploits available ...
Eduardo Abi Jaber +2 more
wiley +1 more source
Journal of Orthopaedic Surgery, 2004 Purpose. To determine the diagnostic utility of waveform analysis of compound muscle action potentials (CMAP) for carpal tunnel syndrome (CTS). Methods.
T Ogura +7 more
doaj +1 more source
Safety of Pulsed Field Ablation: Established Evidence, Emerging Risks, and Knowledge Gaps
Pacing and Clinical Electrophysiology, EarlyView.Overview of the safety profile of pulsed field ablation (PFA), highlighting established safety advantages, procedure‐related complications, electroporation‐specific effects, and key areas of ongoing uncertainty, particularly for ventricular applications.
Dakota de Cecco +3 more
wiley +1 more source
The additional files for the major revision of Cell lineage-resolved embryonic morphological map reveals novel signaling regulating cell fate and size asymmetry (https://www.researchsquare.com/article/rs-4664717/v1)
Zelin Li, Guoye Guan
openaire +1 more source
Concept Map mit Cmap Tools erstellen
, 2015 Im ersten Teil des Tutorials geht es darum, wie mit Hilfe des Programms Cmap Tools eine Concept Map erstellt werden kann. Was ist sind Ziele und Inhalte von gelungenen Concept Maps bzw. Cmaps? Wie wird eine Cmap vorbereitet?
Helen Knauf
core
Schwann Cell‐Specific ATG7‐Dependent Autophagy Protects Myelin in a Mouse Model of Krabbe Disease
Glia, Volume 74, Issue 12, December 2026.Krabbe disease (KD) is caused by mutations in GALC and deregulated lysosomal function in Schwann cells (SCs). Using a SC‐specific Galc‐cKO mouse, we identified altered autophagy in SCs during KD progression. Further ablation of Atg7 in SCs of KD worsened disease severity.
Narayan Dhimal +8 more
wiley +1 more source
Disruption of Lactate Metabolism in the Peripheral Nervous System Leads to Motor‐Selective Deficits
Glia, Volume 74, Issue 12, December 2026.To test the importance of lactate metabolism and shuttling between Schwann cells and neurons in the PNS, we selectively knocked out both LDHA and LDHB in motor neurons, sensory neurons, or Schwann cells. ABSTRACT Schwann cells (SCs) myelinate and provide trophic support to axons in the peripheral nervous system (PNS).
A. Joseph Bloom +11 more
wiley +1 more source
mdashkezari/cmap-agent-paper: CMAP Agnet Paper
Reference repository for CMAP agent CMAP Agent document project. The paper introduces an agentic retrieval-augmented interface for dataset discovery, access, integration, and analysis on Simons CMAP data platform.
openaire +1 more source
Journal of the Peripheral Nervous System, Volume 31, Issue 4, December 2026.ABSTRACT Background and Aims Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) is an immune‐mediated neuropathy that may cause persistent disability despite immunoglobulin treatment. Ion channel dysfunction has been demonstrated in CIDP, but no therapies specifically target this mechanism.
Peter Nørregaard Hansen +5 more
wiley +1 more source