Results 41 to 50 of about 15,154 (201)

Longitudinal Single‐Axon‐Resolution Imaging of Peripheral Nerve Injury Response in Mice Using an Optical Window Implant

Advanced Science, EarlyView.
A minimally invasive optical window enables stable, long‐term imaging of peripheral nerves in vivo at single‐axon resolution. Dynamic processes of degeneration, regeneration, and cellular remodeling are visualized across multiple time scales within the same nerve region, providing a unique platform to study a variety of anatomical and molecular events ...
Igor D. Luzhansky, Emma Anisman, Ron Perez, Sophia Zhang, Morgan Hoffman, Daniel Hunter, Abigail Cherian, Jevon Bonner, Emilia Feria, Ahmed Ahmed, Muneeb Malik, Junwei Du, Leland C. Sudlow, David M. Brogan, Matthew D. Wood, Mikhail Y. Berezin   +15 more
wiley   +1 more source

On a Model for the Storage of Files on a Hardware: Statistics at a Fixed Time and Asymptotic Regimes

Journal of Probability and Statistics, 2009
We consider a version in continuous time of the parking problem of Knuth. Files arrive following a Poisson point process and are stored on a hardware identified with the real line, in the closest free portions at the right of the arrival location.
Vincent Bansaye
doaj   +1 more source

An Inverse Problem Approach for Content Popularity Estimation

EAI Endorsed Transactions on Scalable Information Systems, 2016
The Internet increasingly focuses on content, as exemplified by the now popular Information Centric Networking paradigm. This means, in particular, that estimating content popularities becomes essential to manage and distribute content pieces efficiently.
Felipe Olmos, Bruno Kauffmann
doaj   +1 more source

A Microenvironment‐Adaptive Scaffold Rejuvenates Peripheral Nerve Regeneration During Aging Via Dual Modulation of Ferroptotic Stimuli in Schwann Cells

Advanced Science, EarlyView.
(i) Aging impairs peripheral nerve regeneration via its dual ferroptosis‐mediated pathologies in senescent schwann cells. (ii) The composite nerve conduit is a symbiosis niche integrating microenvironment‐responsive nanoparticles (Ga‐PTAs) and maxillofacial‐derived mesenchymal stem cells (Mmscs).
Ning Zhan, Lixin Tian, Lianjie Peng, Jingyu Zhang, Lining Lin, Xiaoting Zhang, Yaxian Luo, Zhichao Liu, Xinhua Yao, Mouyuan Sun, Yong He, Mengfei Yu, Huiming Wang   +12 more
wiley   +1 more source

Diaphragmatic CMAP Monitoring During Cryoballoon Procedures: Surface vs. Hepatic Recording Comparison and Limitations of This Approach

Frontiers in Cardiovascular Medicine, 2022
BackgroundCompound motor action potential (CMAP) monitoring is a common method used to prevent right phrenic nerve palsy during cryoballoon ablation for atrial fibrillation.ObjectiveWe compared recordings simultaneously obtained with surface and hepatic ...
Lilith Tovmassian, Lilith Tovmassian, Baptiste Maille, Baptiste Maille, Baptiste Maille, Baptiste Maille, Linda Koutbi, Linda Koutbi, Jérôme Hourdain, Jérôme Hourdain, Elisa Martinez, Elisa Martinez, Maxime Zabern, Maxime Zabern, Jean-Claude Deharo, Jean-Claude Deharo, Jean-Claude Deharo, Jean-Claude Deharo, Frédéric Franceschi, Frédéric Franceschi, Frédéric Franceschi, Frédéric Franceschi   +21 more
doaj   +1 more source

Establishing Sensory Neurons as Therapeutic Targets in Peripheral Neuropathy Driven by Polyglutamine Expanded Murine ATXN3

Annals of Neurology, EarlyView.
Repeat expansion disorders frequently involve peripheral neuropathy, yet mechanisms remain unclear. Using a spinocerebellar ataxia type 3 (SCA3) Knock‐In Atxn3Q300/Q6, we identify progressive sensorimotor deficits, peripheral nerve pathology, and dorsal root ganglia RNA splicing dysregulation.
Juan P. Mato, John M. Hayes, Jacen Emerson, Maeha Sridharan, Toluwani Adelaja, Arsal Naeem, Alexandra F. Putka, Hayley S. McLoughlin   +7 more
wiley   +1 more source

Influência de doses de fósforo no fluxo difusivo em solos de Alagoas Influence of phosphorus doses in diffusive flow in the soils of Alagoas

Revista Brasileira de Engenharia Agrícola e Ambiental, 2008
Objetivando avaliar o efeito de diferentes doses de fósforo sobre o fluxo difusivo deste elemento em amostras de solos do Estado de Alagoas, conduziu-se um experimento em laboratório, no Centro de Ciências Agrárias da Universidade Federal de Alagoas ...
Adelmo L. Bastos, José P. V. da Costa, Ivandro de F. da Silva, Roberto W. C. Raposo, Jacob S. Souto   +4 more
doaj   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

Interpretable seasonal multisite hidden Markov model for stochastic rain generation in France [PDF]

Advances in Statistical Climatology, Meteorology and Oceanography
We present a lightweight stochastic weather generator (SWG) based on a multisite hidden Markov model (HMM) trained on a large area with French weather station data.
E. Gobet, D. Métivier, D. Métivier, S. Parey   +3 more
doaj   +1 more source

Retinoic Acid Receptor Is a Novel Therapeutic Target for Postoperative Cognitive Dysfunction

Pharmaceutics, 2023
Postoperative cognitive dysfunction (POCD) is a clinical syndrome characterizing by cognitive impairments in the elderly after surgery. There is limited effective treatment available or clear pathological mechanisms known for this syndrome. In this study,
Yongjie Bao, Wenni Rong, An Zhu, Yuan Chen, Huiyue Chen, Yirui Hong, Jingyang Le, Qiyao Wang, C. Benjamin Naman, Zhipeng Xu, Lin Liu, Wei Cui, Xiang Wu   +12 more
doaj   +1 more source