Results 41 to 50 of about 32,320 (220)

Short Paper - Quadratic minimization: from conjugate gradient to an adaptive Polyak’s momentum method with Polyak step-sizes

Open Journal of Mathematical Optimization
In this work, we propose an adaptive variation on the classical Heavy-ball method for convex quadratic minimization. The adaptivity crucially relies on so-called “Polyak step-sizes”, which consists of using the knowledge of the optimal value of the ...
Goujaud, Baptiste, Taylor, Adrien, Dieuleveut, Aymeric   +2 more
doaj   +1 more source

The underlying molecular mechanism and potential drugs for treatment in papillary renal cell carcinoma: A study based on TCGA and Cmap datasets

Oncology Report, 2019
Papillary renal cell carcinoma (PRCC) accounts for 15–20% of all kidney neoplasms and continually attracts attention due to the increase in the incidents in which it occurs.
Jin-Shu Pang, Zhekun Li, P. Lin, Xiao-dong Wang, Gang Chen, Hai-biao Yan, Sheng-Hua Li   +6 more
semanticscholar   +1 more source

Reinnervation of Muscle Targets Enhances the Separability of Motor Unit Signals Following Peripheral Nerve Transfers

Advanced Science, EarlyView.
Injured or cut peripheral nerves can be surgically rerouted to reinnervate new muscle targets. This study demonstrates reinnervated muscles exhibit enhanced separability between individual motor unit signals, which can simplify signal recording and decomposition. These findings highlight the potential of reinnervated muscle to serve as a key biological
Kiara N Quinn, Siyu Wang, Lang Qin, Alessandro Ascani Orsini, Kenzi Griffith, Rachana Suresh, Fausto Kang, Pierce L Perkins, Neha Joshi, Alexis L Lowe, Sami Tuffaha, Nitish V Thakor   +11 more
wiley   +1 more source

Novel network pharmacology methods for drug mechanism of action identification, pre-clinical drug screening and drug repositioning

, 2011
The high rates of failure in oncology drug clinical trials highlight the problems of using pre-clinical data to predict the clinical effects of drugs. Here we present two methodology innovations on network pharmacology modeling.
Jianghui Xiong
core   +1 more source

CMAP Scan MUNE (MScan) - A Novel Motor Unit Number Estimation (MUNE) Method.

Journal of Visualized Experiments, 2018
Like other methods for motor unit number estimation (MUNE), compound muscle action potential (CMAP) scan MUNE (MScan) is a non-invasive electrophysiologic method to estimate the number of functioning motor units in a muscle. MUNE is an important tool for
A. B. Jacobsen, H. Bostock, H. Tankişi
semanticscholar   +1 more source

Longitudinal Single‐Axon‐Resolution Imaging of Peripheral Nerve Injury Response in Mice Using an Optical Window Implant

Advanced Science, EarlyView.
A minimally invasive optical window enables stable, long‐term imaging of peripheral nerves in vivo at single‐axon resolution. Dynamic processes of degeneration, regeneration, and cellular remodeling are visualized across multiple time scales within the same nerve region, providing a unique platform to study a variety of anatomical and molecular events ...
Igor D. Luzhansky, Emma Anisman, Ron Perez, Sophia Zhang, Morgan Hoffman, Daniel Hunter, Abigail Cherian, Jevon Bonner, Emilia Feria, Ahmed Ahmed, Muneeb Malik, Junwei Du, Leland C. Sudlow, David M. Brogan, Matthew D. Wood, Mikhail Y. Berezin   +15 more
wiley   +1 more source

Forward implied volatility expansion in time-dependent local volatility models******

ESAIM: Proceedings and Surveys, 2014
We introduce an analytical approximation to efficiently price forward start options on equity in time-dependent local volatility models as the forward start date, the maturity or the volatility coefficient are small.
Bompis Romain, Hok Julien
doaj   +1 more source

Application of connectivity map technology in traditional Chinese medicines

浙江大学学报. 农业与生命科学版, 2016
Connectivity map (CMap) technology was initially developed in Broad Institute of Massachusetts Institute of Technology and Harvard. It has been widely used to investigate mechanism of action of drug by academic research institutes and pharmaceutical ...
ZHANG Xiaofang, KANG Yongbo, SU Junhong, KONG Xiangyang   +3 more
doaj   +1 more source

A novel bifunctional hybrid with marine bacterium alkaline phosphatase and Far Eastern holothurian mannan-binding lectin activities. [PDF]

PLoS ONE, 2014
A fusion between the genes encoding the marine bacterium Cobetia marina alkaline phosphatase (CmAP) and Far Eastern holothurian Apostichopus japonicus mannan-binding C-type lectin (MBL-AJ) was performed. Expression of the fusion gene in E.
Larissa Balabanova, Vasily Golotin, Svetlana Kovalchuk, Alexander Bulgakov, Galina Likhatskaya, Oksana Son, Valery Rasskazov   +6 more
doaj   +1 more source

The Amplitude of Diaphragm Compound Muscle Action Potential Correlates With Diaphragmatic Excursion on Ultrasound and Pulmonary Function After Supraclavicular Brachial Plexus Block

Frontiers in Medicine, 2022
ObjectiveThis prospective, double-blind, randomized study assessed (1) the associations between diaphragm compound muscle action potential (CMAP), hemidiaphragmatic excursion, and pulmonary function after supraclavicular brachial plexus block (SCBPB) and
Xiuxia Bao, Tao Liu, Haorong Feng, Yeke Zhu, Yingying Wu, Xianghe Wang, Xianhui Kang   +6 more
doaj   +1 more source