Results 51 to 60 of about 32,320 (220)

Monoallelic POLR3A Variants Cause Early‐Onset Peripheral Neuropathy

Annals of Neurology, EarlyView.
Objective Biallelic variants in genes encoding the RNA polymerase III complex (Pol III) cause a spectrum of neurological disorders primarily affecting the central nervous system. Monoallelic variants have been reported in the POLR3B subunit only, associated with neurodevelopmental disorder, epilepsy, and peripheral neuropathy.
Luiza L. P. Ramos, Jevin M. Parmar, Robin Wijngaard, Bianca R. Grosz, Tamas Lazar, Ligia Mateiu, Steve Vucic, Kishore R. Kumar, Dennis Yeow, Laura I. Rudaks, Lonneke de Boer, Annemarie de Vreugd, David A. Koolen, Thatjana Gardeitchik, Anita Cairns, Krishnan Iyengar, Fernando Kok, Fernanda Barbosa Figueiredo, Alzira Alves de Siqueira Carvalho, Luiz S. Mageste Barbosa, Rodrigo Rezende Arantes, Tyler Rehbein, Jordan E. Bontrager, Elizabeth P. Wood, Janet E. Sowden, Gavin Monahan, Meutia Kumaheri, Ivy Cuijt, Melina Ellis, Gonzalo Perez‐Siles, Elyshia McNamara, Ronald van Beek, Celine B. Meijers, Ivaylo Tournev, Stephan Zuchner, Shoshana J. Wodak, Clara D. M. van Karnebeek, Nigel Laing, Liana N. Semcesen, David A. Stroud, David N. Herrmann, Velina Guergueltcheva, Marina L. Kennerson, Machteld M. Oud, Gianina Ravenscroft, Ayse Candayan, Albena Jordanova   +46 more
wiley   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

On a Model for the Storage of Files on a Hardware: Statistics at a Fixed Time and Asymptotic Regimes

Journal of Probability and Statistics, 2009
We consider a version in continuous time of the parking problem of Knuth. Files arrive following a Poisson point process and are stored on a hardware identified with the real line, in the closest free portions at the right of the arrival location.
Vincent Bansaye
doaj   +1 more source

Design of experiments based on a low fidelity model for seismic fragility curves estimation [PDF]

ESAIM: Proceedings and Surveys
Seismic fragility curves are key quantities of interest for Seismic Probabilistic Risk Assessment studies. They express the probability of failure of a mechanical structure of interest conditional to a scalar value derived from the ground motion signal ...
Van Biesbroeck Antoine, Gauchy Clément, Feau Cyril, Garnier Josselin   +3 more
doaj   +1 more source

Emerging Human‐Based Research Technologies for Investigating the Pathomechanisms and Therapies for Vascular Diseases

iNew Medicine, EarlyView.
ABSTRACT It is estimated that a large proportion of drug candidates fail in human clinical trials, mainly because animal models cannot fully replicate human disease and because of differential responses to various medications between humans and animals.
Weiping Ding, Iqra Ilyas, Suowen Xu
wiley   +1 more source

Generative Artificial Intelligence–Driven Clinical Case Simulation in Temporomandibular Disorder Education: ChatGPT Versus Real Patients

Journal of Dental Education, EarlyView.
ABSTRACT Background Temporomandibular disorders (TMDs) and orofacial pain (OFP) demand advanced diagnostic and clinical reasoning skills in dental education. Traditional simulations with real patients face limitations in availability and standardization.
Paula Rodrigues‐Pereira, Maria Amália Pereira Dias‐Calças, Alex Moreira Mélo, Melissa de Oliveira Melchior, Lucas Gaspar Ribeiro, Antônio Pazin‐Filho, Jardel Francisco Mazzi‐Chaves, Laís Valencise Magri   +7 more
wiley   +1 more source

Motor unit number of the first dorsal interosseous muscle estimated from CMAP scan with different pulse widths and steps

Journal of Neural Engineering, 2019
Objective. A compound muscle action potential (CMAP) scan has different settings such as stimulus frequency, duration (or pulse width), and the number of stimuli (or steps).
Ya Zong, Zhiyuan Lu, Lining Zhang, Xiaoyan Li, P. Zhou   +4 more
semanticscholar   +1 more source

An Inverse Problem Approach for Content Popularity Estimation

EAI Endorsed Transactions on Scalable Information Systems, 2016
The Internet increasingly focuses on content, as exemplified by the now popular Information Centric Networking paradigm. This means, in particular, that estimating content popularities becomes essential to manage and distribute content pieces efficiently.
Felipe Olmos, Bruno Kauffmann
doaj   +1 more source

Time‐Continuous Prognostic Mapping of Bell's Palsy Using Yanagihara Scores and Electroneurography

The Laryngoscope, EarlyView.
This study developed a novel, time‐continuous prognostic mapping for Bell's palsy by integrating longitudinal Yanagihara scores and electroneurography in patients treated with high‐dose corticosteroids. By employing a Bayesian probabilistic approach, this model enables individualized recovery estimation at any clinical time point, overcoming the ...
Shogo N. Watanabe, Shumpei Hisamoto, Kazuo Yasuhara, Kenji Kondo, Hironobu Nishijima   +4 more
wiley   +1 more source

Adsorção de fósforo em solos sob floresta e savana do Norte Amazônico, Brasil

Semina: Ciências Agrárias, 2017
Estudos sobre capacidade máxima de adsorção de fósforo (CMAP) em solos de Roraima e atributos que interferem na magnitude dessa característica são relevantes e motivaram esse trabalho.
Carlos Henrique de Lima Matos, Valdinar Ferreira Melo, Sandra Cátia Pereira Uchôa, Pedro Paulo Ramos Ribeiro Nascimento, Raimundo Almeida Pereira   +4 more
doaj   +3 more sources