Results 91 to 100 of about 216,439 (378)

Organization of the Proteostasis Network of Membraneless Organelles

Advanced Science, EarlyView.
A comprehensive mapping of the proteostasis network (PN) across membraneless organelles (MLOs) reveals how central PN components coordinate MLO regulation. The analysis uncovers principles of specificity and promiscuity within the PN. The findings suggest that HSP70 chaperones act as generic MLO regulators, while client specific HSP70 co‐chaperones may
Christine M. Lim, Yuqi Bian, Alicia González Díaz, Frank Pun, Alex Zhavoronkov, Richard I. Morimoto, Michele Vendruscolo   +6 more
wiley   +1 more source

Compound mutations in BCR-ABL1 are not major drivers of primary or secondary resistance to ponatinib in CP-CML patients.

Blood, 2016
BCR-ABL1 kinase domain mutations can confer resistance to first- and second-generation tyrosine kinase inhibitors (TKIs) in chronic myeloid leukemia (CML).
M. Deininger, J. Hodgson, N. Shah, J. Cortes, Dong-Wook Kim, F. Nicolini, M. Talpaz, M. Baccarani, Martin C. Müller, Jin Li, W. Parker, S. Lustgarten, T. Clackson, F. Haluska, F. Guilhot, H. Kantarjian, S. Soverini, A. Hochhaus, T. Hughes, T. Hughes, V. Rivera, S. Branford, S. Branford   +22 more
semanticscholar   +1 more source

Antecedent CHIP in CML? [PDF]

Blood, 2017
In this issue of Blood, Kim et al provide evidence that the t(9:22) translocation (ie, Philadelphia chromosome, or Ph), coding for the BCR/ABL gene rearrangement, is not always the first mutation acquired in chronic myeloid leukemia (CML).1 These results are consistent with prior smaller studies and indicate that CML can sometimes arise from a ...
openaire   +3 more sources

Fast pH‐Driven Solubilization Method of Realgar (As4S4) to Reduce the Toxicity of Arsenic [As(III)] for Medicinal Purposes

Advanced Science, EarlyView.
Arsenic trioxide transformed acute promyelocytic leukemia therapy and shows promise against HIV. A new method to solubilize the mineral realgar produces different arsenic species depleting the main arsenic target, nuclear PML protein, and retaining effects on leukemic and HIV reservoir cells, while minimizing off‐target damage.
Bojana Lucic, Douglas Santana Franciscato, Helton Pereira Nogueira, Lara Gallucci, Alceu Totti Silveira Junior, Asmaa Mohamed Ismail, Millie Robinson, Teresa Dallinger, Claudia Gutfleisch, Jochen Kurz, Maytê Toledo, Jessica Dias da Silva Ferraz, Mohammad Tarek, Danilo Dias, Ricardo Sobhie Diaz, Mahmoud ElHefnawi, Mattia Forcato, Hugo P Monteiro, Marina Lusic, Iart Luca Shytaj, Andrea Savarino   +20 more
wiley   +1 more source

IL1RAP antibodies block IL-1-induced expansion of candidate CML stem cells and mediate cell killing in xenograft models.

Blood, 2016
Chronic myeloid leukemia (CML) is currently treated with tyrosine kinase inhibitors, but these do not effectively eliminate the CML stem cells. As a consequence, CML stem cells persist and cause relapse in most patients upon drug discontinuation ...
H. Ågerstam, N. Hansen, Sofia von Palffy, Carl Sandén, K. Reckzeh, C. Karlsson, H. Lilljebjörn, N. Landberg, M. Askmyr, Carl Högberg, M. Rissler, K. Porkka, H. Wadenvik, S. Mustjoki, J. Richter, M. Järås, T. Fioretos   +16 more
semanticscholar   +1 more source

Quantum Kernel Learning for Small Dataset Modeling in Semiconductor Fabrication: Application to Ohmic Contact

Advanced Science, EarlyView.
A quantum kernel‐aligned regressor (QKAR) is developed for modeling Ohmic contact formation in GaN HEMT fabrication. Leveraging experimental data and a Pauli‐Z feature map enhanced with a quantum kernel alignment (QKA) layer, the model achieves superior predictive performance over classical methods.
Zeheng Wang, Fangzhou Wang, Liang Li, Zirui Wang, Timothy van der Laan, Ross C. C. Leon, Jing‐Kai Huang, Muhammad Usman   +7 more
wiley   +1 more source

Enhancing Maritime Navigation with Mixed Reality: Assessing Remote Pilotage Concepts and Technologies by In Situ Testing

Journal of Marine Science and Engineering
In response to the evolving landscape of maritime operations, new technologies are on the horizon as mixed reality (MR), which shall enhance navigation safety and efficiency during remote assistance as, e.g., in the remote pilotage use case.
Arbresh Ujkani, Pascal Hohnrath, Robert Grundmann, Hans-Christoph Burmeister   +3 more
doaj   +1 more source

Trimetal-based nanomaterials induced toxicity to plants: Does it differ from the toxicity of mixed and single-element nanoparticles?

Heliyon, 2023
Advanced materials comprising multiple metal alloys have made their way into the market. Trimetal-based nanomaterials (TNMs) are an example of advanced materials which have gained significant traction and are now employed in a wide array of products.
Yuchao Song, Mieke van Vlaardingen, Frank Senden, Willie J.G.M. Peijnenburg, Martina G. Vijver   +4 more
doaj  

On Harder-Narasimhan filtrations and their compatibility with tensor products [PDF]

, 2018
We attach buildings to modular lattices and use them to develop a metric approach to Harder-Narasimhan filtrations. Switching back to a categorical framework, we establish an abstract numerical criterion for the compatibility of these filtrations with ...
Cornut, Christophe
core   +3 more sources

Flame‐Retardant Ionogel Enabled by Lignin Molecular Networks for Fire Rescue

Advanced Science, EarlyView.
Wearable sensors for harsh, high‐temperature, fire‐prone environments face challenges in heat resistance and stability. This study introduces a flame‐retardant, waterproof glycol lignin ionogel (GLI) with a robust 3D network, exceptional tensile strength, strong adhesion, biocompatibility, eco‐safety, and dual temperature‐motion sensing, even after ...
Zewei Ye, Haomeng Yu, Hongxia Xie, Wenwen Zhu, Shitao Shi, Chencong Liu, Yuanyuan Wang, Jiaqi Liao, Qingfeng Sun, Dawei Zhao, Xiaoping Shen   +10 more
wiley   +1 more source