Results 131 to 140 of about 216,439 (378)

Imaging‐Based High‐Content Screening with Clickable Probes Identifies XPB Inhibitors

Angewandte Chemie International Edition, Accepted Article.
High‐content screening (HCS) has become a powerful tool in drug discovery; however, its reliance on indirect readouts and surrogate markers limits HCS’s ability to directly assess drug‐protein interactions at endogenous levels, particularly in subcellular contexts.
Shuqi Li, Hong-Rui Zhang, Yang Yang, Ben Chi-Bun Ko, Jin Shang, Haijun Guo, Dan Yang, Mankin Wong, Ricky Wing-Cheung Chan, Karen Ka-Yan Kung, Qian Zhao   +10 more
wiley   +1 more source

Hydrogenation of acid oils with in situ hydrogen generation for biofuel production

Biofuels, Bioproducts and Biorefining, EarlyView.
Abstract A sustainable hydrogen source is essential for improving the environmental performance of industries that are heavily reliant on hydrogen. Transitioning from commercial hydrogen to cleaner sources is vital for reducing fossil fuel dependence.
Bruna Ricetti Margarida, Isadora Zangari Ambrosio, Luís Ricardo Shigueyuki Kanda, Aline Andreza da Cruz Lima, Angelita Nepel, Andersson Barison, Marcos L. Corazza, Luiz Fernando de Lima Luz Júnior   +7 more
wiley   +1 more source

The identification of complex spatiotemporal patterns using Coupled map lattice model [PDF]

, 2006
Many complex and interesting spatiotemporal patterns have been observed in a wide range of scienti¯c areas. In this paper, two kinds of spatiotemporal patterns including spot replication and Turing systems are investigated and new identi¯cation methods ...
Billings, S.A., Pan, Y.
core  

Optimized Treatment Schedules for Chronic Myeloid Leukemia

, 2016
Over the past decade, several targeted therapies (e.g. imatinib, dasatinib, nilotinib) have been developed to treat Chronic Myeloid Leukemia (CML). Despite an initial response to therapy, drug resistance remains a problem for some CML patients.
Dingli, David, Foo, Jasmine, He, Qie, Leder, Kevin, Zhu, Junfeng   +4 more
core   +3 more sources

Sustainable Decision‐Making in SMEs of the Textile Industry: Integrating Methodologies, Practices, and Barriers

Business Strategy and the Environment, EarlyView.
ABSTRACT Despite its economic importance, the textile industry is one of the most polluting sectors. This study addresses the critical gap in understanding sustainable decision‐making in textile SMEs, where decision processes often remain informal and lack structured frameworks.
Israel Naranjo, Rocío de la Torre, Andres Boza   +2 more
wiley   +1 more source

Cases of Patients Treated in Countries With Limited Resources and Discussed by Experts of the International CML Foundation (iCMLf)—Case No. 1: A Boy Presenting With Priapism and Loss of Vision

Case Reports in Oncological Medicine
Pediatric chronic myeloid leukemia (pCML) is a rare malignancy accounting for only 2%–3% of all childhood leukemias. Due to this rarity, familiarity with pCML is limited among most pediatric practitioners, including even pediatric hemato-oncologists.
Nirmalya Roy Moulik, Arlene Harriss-Buchan, Guiseppe Saglio, Nicola Evans, Meinolf Suttorp   +4 more
doaj   +1 more source

Deep molecular response is reached by the majority of patients treated with imatinib, predicts survival, and is achieved more quickly by optimized high-dose imatinib: results from the randomized CML-study IV.

Journal of Clinical Oncology, 2014
PURPOSE Deep molecular response (MR(4.5)) defines a subgroup of patients with chronic myeloid leukemia (CML) who may stay in unmaintained remission after treatment discontinuation. It is unclear how many patients achieve MR(4.5) under different treatment
R. Hehlmann, Martin C. Müller, M. Lauseker, B. Hanfstein, A. Fabarius, Annette Schreiber, U. Proetel, Nadine Pletsch, M. Pfirrmann, C. Haferlach, S. Schnittger, H. Einsele, J. Dengler, C. Falge, L. Kanz, A. Neubauer, M. Kneba, F. Stegelmann, M. Pfreundschuh, C. Waller, K. Spiekermann, G. Baerlocher, G. Ehninger, D. Heim, H. Heimpel, C. Nerl, S. Krause, D. Hossfeld, H. Kolb, J. Hasford, S. Saussele, A. Hochhaus   +31 more
semanticscholar   +1 more source

Promising Prodiginins Biological Activities

Chemistry &Biodiversity, EarlyView.
ABSTRACT Prodiginins are a large family of at least 34 pyrrolic compounds, including the well‐studied red pigment prodigiosin. Prodiginins are produced by several microorganisms displaying broad biological activities, including antimicrobial, antiviral, antiparasitic, antiproliferative, and immunosuppressive activities.
María F. Ladetto, Melisa E. Gantner, Boris E. Rodenak‐Kladniew, Santiago Rodriguez, María L. Cuestas, Alan Talevi, Guillermo R. Castro   +6 more
wiley   +1 more source

Chromosomes and causation of human cancer and leukemia.XXIX.Further studies on karyotypic progression in CML [PDF]

, 1978
Shin‐ichi Sonta, Avery A. Sandberg
openalex   +1 more source

Piper auritum (Kunth) Fungal Endophytes: A Source of Metabolites to Inhibit the Formation of Advanced Glycation End Products

Chemistry &Biodiversity, EarlyView.
Endophytic fungi of P. auritum were evaluated for their ability to produce inhibitors of formation of advanced glycation end products (AGEs). Neopestalotiopsis sp. H2 and Diaporthe sp. H5 extracts were the most active. So, we performed their chemical profiling by untargeted and phenolics‐targeted metabolomic approaches to identify the potential ...
Lory Sthephany Rochín‐Hernández, José Antonio Guerrero‐Analco, Juan Luis Monribot‐Villanueva, Luis Bernardo Flores‐Cotera   +3 more
wiley   +1 more source