Results 111 to 120 of about 197,689 (281)

Biodegradable Carbonate Nanogels Loaded with Anti MFAP‐5 siRNA for Anti‐stromal Therapy of Hepatocellular Carcinoma

Advanced Science, EarlyView.
Polycarbonate nanogels enable lipid‐free delivery of anti‐MFAP‐5 siRNA into cancer‐associated fibroblasts (CAF) in hepatocellular carcinoma. In a cirrhotic murine model, this approach silences MFAP‐5, reduces fibroblast activation, and suppresses tumor growth by inhibiting NOTCH/Hes1‐driven angiogenesis. CAF‐targeted MFAP‐5 RNAi and conserved signaling
Paul Schneider, Alexander Fuchs, Michael Fichter, Vanessa Bolduan, Jenny Schunke, Özlem Akilli, Nádia C. Correia, Yannick Ehlers, Christian Czysch, Pia Winterwerber, Eliana Stanganello, Barbara Schrörs, Mustafa Diken, Christoph Eckert, Shusruto Rishik, Andreas Keller, Jörn M. Schattenberg, Stephan Grabbe, Matthias Bros, Lutz Nuhn, Leonard Kaps   +20 more
wiley   +1 more source

Tumor-targeted Chlorotoxin-coupled Nanoparticles for Nucleic Acid Delivery to Glioblastoma Cells: A Promising System for Glioblastoma Treatment

Molecular Therapy: Nucleic Acids, 2013
The present work aimed at the development and application of a lipid-based nanocarrier for targeted delivery of nucleic acids to glioblastoma (GBM). For this purpose, chlorotoxin (CTX), a peptide reported to bind selectively to glioma cells while showing
Pedro M Costa, Ana L Cardoso, Liliana S Mendonça, Angelo Serani, Carlos Custódia, Mariana Conceição, Sérgio Simões, João N Moreira, Luís Pereira de Almeida, Maria C Pedroso de Lima   +9 more
doaj   +1 more source

Allogeneic Immune Cell Perfusion Inhibits the Growth of Vascularized 3D In Vitro Tumor Models, Induces Vascular Regression and Desmoplasia, but Promotes Tumor Cell Invasion

Advanced Science, EarlyView.
This study presents a vascularized 3D tumor model to investigate immune–stromal–tumor interactions under allogeneic PBMC perfusion. While immune cells induced tumor shrinkage, they also promoted vascular regression, stromal activation, and cancer cell invasion.
Alexandra Raab, Rasika Daware, Marcelo A. Szymanski de Toledo, Oskar Weber, Dimitris Kapsokalyvas, Twan Lammers, Horst Fischer, Federica De Lorenzi, Fabian Kiessling   +8 more
wiley   +1 more source

Rib‐Reinforced Ultralight and Ultra‐Strong Shell Lattices

Advanced Science, EarlyView.
This study thoroughly reveals the relation between the curvature and stress direction of triply periodic minimal surface (TPMS) thin shell lattices and proposes a novel rib reinforcement design strategy to incorporate ribs along the line of asymptotes (LOA) and the line of principal curvatures (LOC) to enhance the strength of ultralight TPMS shell ...
Winston Wai Shing Ma, Lei Zhang, Junhao Ding, Shuo Qu, Michael Yu Wang, Xu Song, Ming Wang Fu   +6 more
wiley   +1 more source

Design, Construction, and Evaluation of an Air Filtration System Based on a Nanofiber Filter Containing a Metal-Organic Framework for the Removal of Aerosols Emitted from CNC Machining Operations [PDF]

بهداشت و ایمنی کار
Introduction: With the advancement of industries and increased use of metalworking fluids, controlling pollutants generated by machining operations has become increasingly challenging.
Mehrdad Helmi Kohnehshahri, Farideh Golbabaei, Somayeh Farhang Dehghan, Rezvan Zendehdel, Alireza Abbasi, Zahra Yadegar   +5 more
doaj  

Rancang Bangun Jig & Fixture Pemesinan Computer Numerical Control (CNC) Milling Dengan Area Kerja 300x300mm

Infotekmesin: Media Komunikasi Ilmiah Politeknik Cilacap
Limitations in machining accuracy and efficiency on CNC milling machines with a 300 × 300 mm working area are often caused by the use of general-purpose jig and fixture (J&F) designs that are not tailored to the characteristics of the machine and ...
Nur Aidi Ariyanto, Sigit Setijo Budi
doaj   +1 more source

Near-Infrared properties of the X-ray emitting young stellar objects in the Carina Nebula

, 2011
Abbreviated Abstract: The near-infrared study of the Carina Nebula in this paper builds on the results of the Chandra Carina Complex Project (CCCP), that detected 14368 X-ray sources in the 1.4 square-degree survey region, an automatic source ...
Broos, Patrick, Hodgkin, Simon, Irwin, Mike, King, Robert R., Lewis, James R., McCaughrean, Mark J., Preibisch, Thomas, Townsley, Leisa, Zinnecker, Hans   +8 more
core   +1 more source

Thermally Induced Creep and Viscoelastic Behavior of Copper Micropillar Arrays

Advanced Science, EarlyView.
Copper micropillar arrays are fabricated by electrodeposition within through‐glass‐via, and their thermally induced time‐dependent deformation is quantified. Nanoindentation creep, EBSD, and TEM reveal a heat‐treatment‐driven transition between grain‐boundary‐mediated deformation and dislocation‐dominated creep, while Kelvin modeling captures ...
Miao Wang, Jihua Zhang, Libin Gao, Hongwei Chen, Wenbo Luo, Wenlei Li, Mingcheng Chen, Mengru Li, Dongbin Wang, Shuang Li, Ting Liu, Xingzhou Cai, Yong Li, Bin Peng, Wanli Zhang   +14 more
wiley   +1 more source

Sustainable Phosphorylated Cellulose Nanocrystals: A Dual‐Affinity Platform for High‐Efficiency Enrichment of Intact Glycopeptides and Phosphopeptides

Advanced Science, EarlyView.
AAA ABSTRACT Protein glycosylation and phosphorylation are critical post‐translational modifications (PTMs) governing nearly all cellular functions, yet their analysis remains challenging due to reliance on costly and unsustainable enrichment materials.
Jiaying Li, Wuming Fan, Xuyang Yue, Dongdong Wang, Xiangyu Tang, Zhuo Zhang, Yonggui Wang, Yanjun Xie, Mingliang Ye, Hongqiang Qin   +9 more
wiley   +1 more source

REKAYASA CNC TURNING SEBAGAI MEDIA PEMBELAJARAN CNC

Jurnal Kependidikan: Penelitian Inovasi Pembelajaran, 2016
ABSTRACT Engineering CNC Turning aims; (1) produce a prototype, which is capable of a teaching aids, and resources of CNC programming. Engineering conducted following the procedures Research and Development (R D) expressed Borg and Gall. Starting with a needs study of teaching aids/media of CNC programming; defining products (define); designing a ...
openaire   +1 more source