Results 31 to 40 of about 132,611 (311)

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Multi-energy computed tomography breast imaging with Monte Carlo simulations: Contrast-to-noise-based image weighting

Journal of Medical Physics, 2019
Context: Photon-counting detectors and breast computed tomography imaging have been an active area of research. With these detectors, photons are assigned an equal weight and weighting schemes can be enabled. More weight can be assigned to lower energies,
Déte Van Eeden, Freek C. P Du Plessis
doaj   +1 more source

The Feasibility of Contrast-to-Noise Ratio on Measurements to Evaluate CT Image Quality in Terms of Low-Contrast Detailed Detectability

Medical Sciences, 2020
Background: To evaluate contrast-to-noise ratio (CNR) measurements in assessing image quality, in the context of the detectability performance of low-contrast detail (LCD), in computed tomography (CT) images, since exposure to elevated ionising-type ...
Haney A Alsleem, Hussain M Almohiy
doaj   +1 more source

Rapporto finale del progetto “Miglioramento del Servizio di Energy Management del CNR con la partecipazione dei dipendenti”(ENERGY+) - con allegati sulle principali attività svolte [PDF]

, 2017
Relazione finale del progetto Energy+ (progetto vincitore del Premio Innovazione CNR 2013) con descrizione dei risultati ottenuti. In allegato sono riportati tutti i rapporti tecnici realizzati nel corso del progetto (9 allegati)
Delle Site, Vincenzo, Di Cristofalo, Salvatore   +1 more
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Utility of liquid‐based cytology on residual needle rinses collected from core needle biopsy for lung nodule diagnosis

Cancer Medicine, 2021
Background Core needle biopsy (CNB) has become the most common tissue sampling modality for pathological diagnosis of peripheral lung nodules. However, approximately 10% of pulmonary CNB specimens cannot be unambiguously diagnosed, even with auxiliary ...
Zhihua Lan, Xiaoli Zhang, Xin Ma, Yiyan Hu, Jing Zhang, Fang Yang   +5 more
doaj   +1 more source

Neuromelanin magnetic resonance imaging of substantia nigra and locus coeruleus in Parkinson’s disease with freezing of gait

Frontiers in Aging Neuroscience, 2023
BackgroundThe downregulation of monoamines, especially dopamine in substantia nigra (SN) and norepinephrine in locus coeruleus (LC), may be responsible for freezing of gait (FOG) pathological basis in Parkinson’s disease (PD).MethodsThirty-two Parkinson ...
Shangpei Wang, Tong Wu, Yajie Cai, Yongqiang Yu, Xianwen Chen, Longsheng Wang   +5 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Le prove scritte all’esame di Stato d’abilitazione all’esercizio della professione di Geometra per l’anno 2006

GEOmedia, 2006
La prima prova è stata, more solito, quella di progettazione edile. L’inizio è subito censurabile: “Un locale rettangolare di 20 x 30 m e 4.00 m di altezza è situato al piano terreno di una palazzina di civile abitazione.
Attilio Selvini
doaj   +2 more sources

PEMODELAN GEOGRAPHICALLY WEIGHTED RIDGE REGRESSION PADA KASUS TUBERKULOSIS DI INDONESIA

E-Jurnal Matematika
Tuberculosis remains a major public health issue in Indonesia, with substantial variation in case notification rates (CNR) across provinces, indicating the presence of spatial heterogeneity and potential multicollinearity among influencing factors.
NI PUTU EKA MARTINI, NI LUH PUTU SUCIPTAWATI, ANGGUN YULIARUM QUR’ANI   +2 more
doaj   +1 more source