Results 31 to 40 of about 4,840 (178)

Early-life adversities compromise behavioral development in male and female mice heterozygous for CNTNAP2 [PDF]

Neurobiology of Stress
The etiological complexity of psychiatric disorders arises from the dynamic interplay between genetic and environmental vulnerabilities. Among the environmental components, early-life adversities are a major risk factor for developing a psychiatric ...
Gabriele Chelini, Tommaso Fortunato-Asquini, Enrica Cerilli, Katia Monsorno, Benedetta Catena, Ginevra Matilde Dall’O’, Rosa Chiara Paolicelli, Yuri Bozzi   +7 more
doaj   +2 more sources

Dysregulation of Parvalbumin Expression in the Cntnap2−/− Mouse Model of Autism Spectrum Disorder [PDF]

Frontiers in Molecular Neuroscience, 2018
Due to the complex and heterogeneous etiology of autism spectrum disorder (ASD), identification of convergent pathways and/or common molecular endpoints in the pathophysiological processes of ASD development are highly needed in order to facilitate ...
Emanuel Lauber, Federica Filice, Beat Schwaller   +2 more
doaj   +2 more sources

A study of the role of the FOXP2 and CNTNAP2 genes in persistent developmental stuttering [PDF]

Neurobiology of Disease, 2014
A number of speech disorders including stuttering have been shown to have important genetic contributions, as indicated by high heritability estimates from twin and other studies.
Tae-Un Han, John Park, Carlos F. Domingues, Danilo Moretti-Ferreira, Emily Paris, Eduardo Sainz, Joanne Gutierrez, Dennis Drayna   +7 more
doaj   +4 more sources

Biophysical and Structural Studies of CNTNAP2 [PDF]

, 2021
At synapses, cell adhesion molecules provide connection between the presynaptic and postsynaptic membranes through homophilic and heterophilic interactions promoting synapse development, function, and plasticity. The synaptic adhesion molecules contactin
Kalichava, Ana
core   +3 more sources

CNTNAP2 intracellular domain (CICD) generated by γ-secretase cleavage improves autism-related behaviors

Signal Transduction and Targeted Therapy, 2023
As the most prevalent neurodevelopmental disorders in children, autism spectrum disorders (ASD) are characterized by deficits in language development, social interaction, and repetitive behaviors or inflexible interests. Contactin associated protein like
Jing Zhang, Fang Cai, Renbin Lu, Xiaoliang Xing, Lu Xu, Kunyang Wu, Zishan Gong, Qing Zhang, Yun Zhang, Mengen Xing, Weihong Song, Jia-Da Li   +11 more
doaj   +1 more source

CNTNAP2 is targeted to endosomes by the polarity protein PAR3 [PDF]

European Journal of Neuroscience, 2019
Abstract A decade of genetic studies has established contactin‐associated protein‐like 2 ( CNTNAP2 ) as a prominent susceptibility gene associated with multiple neurodevelopmental disorders. The development and characterization of Cntnap2
Ruoqi Gao, Christopher P. Pratt, Sehyoun Yoon, Maria Dolores Martin‐de‐Saavedra, Marc P. Forrest, Peter Penzes   +5 more
openaire   +2 more sources

The role of contactin-associated protein-like 2 in neurodevelopmental disease and human cerebral cortex evolution

Frontiers in Molecular Neuroscience, 2022
The contactin-associated protein-like 2 (CNTNAP2) gene is associated with multiple neurodevelopmental disorders, including autism spectrum disorder (ASD), intellectual disability (ID), and specific language impairment (SLI).
Frances St. George-Hyslop, Frances St. George-Hyslop, Toomas Kivisild, Toomas Kivisild, Frederick J. Livesey   +4 more
doaj   +1 more source

Investigating behavioral phenotypes related to autism spectrum disorder in a gene-environment interaction model of Cntnap2 deficiency and Poly I:C maternal immune activation

Frontiers in Neuroscience, 2023
IntroductionAutism Spectrum Disorder (ASD) has been associated with a wide variety of genetic and environmental risk factors in both human and preclinical studies.
Faraj L. Haddad, Faraj L. Haddad, Cleusa De Oliveira, Susanne Schmid, Susanne Schmid   +4 more
doaj   +1 more source

Association of GDNF and CNTNAP2 gene variants with gambling [PDF]

Journal of Behavioral Addictions, 2019
Background and aims Some form of gambling can be observed in nearly every society, as the gratification felt upon winning in uncertain conditions is universal. A culturally distinct form of gambling, associated with a traditional sporting event of archery known as “teer,” is innate to the province of Meghalaya, India. The objective
Das, Arundhuti, Pagliaroli, Luca, Vereczkei, Andrea, Kótyuk, Eszter, Langstieh, Banrida, Demetrovics, Zsolt, Barta, Csaba   +6 more
openaire   +4 more sources

Altered cingulate structures and the associations with social awareness deficits and CNTNAP2 gene in autism spectrum disorder

NeuroImage: Clinical, 2021
Backgrounds: Although evidence suggests that the activity of the anterior cingulate cortex involves social cognition, there are inconsistent findings regarding the aberrant cingulate gray matter (GM) and scanty evidence about altered cortical thickness ...
Yi-Ling Chien, Yu-Chieh Chen, Susan Shur-Fen Gau   +2 more
doaj   +1 more source