Results 1 to 10 of about 3,617 (131)

Expanding the clinical spectrum of pediatric CASPR2 antibody-associated autoimmune encephalitis: a multicenter case series [PDF]

Frontiers in Immunology
IntroductionContactin-associated protein-like 2 (CASPR2) antibody-associated autoimmune encephalitis is rare in children, and available clinical data are limited.
Fanni Szumutku, Léna Szabó, Zoltán Liptai, Beáta Rosdy, Gabriella Merő, Márk Merza, Andrea Skobrák, Csaba Zsiborás, Eszter Barabás, Sarolta Dobner   +9 more
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Heterogeneity of anti-Caspr2 antibodies: specificity and pathogenicity [PDF]

Translational Psychiatry
Maternal anti-Caspr2 (Contactin-associated protein-like 2) antibodies have been associated with increased risk for autism spectrum disorder (ASD). Previous studies have shown that in utero exposure to anti-Caspr2 antibodies results in a phenotype with ...
Julia Su, Rohan Gupta, Scott van Hoof, Jakob Kreye, Harald Prüß, Benjamin Spielman, Lior Brimberg, Bruce T. Volpe, Patricio T. Huerta, Betty Diamond   +9 more
doaj   +2 more sources

CASPR2 antibody-related neurological syndromes in children: three cases report and literature review [PDF]

BMC Pediatrics
Background Contactin-associated protein-like 2 (CASPR2) antibody-related neurological syndrome is well defined in adults, while data in children is rare.
Long-Ying Peng, Shu-Jing Pan, Ren-Ke Li, Juan Li, Jing Chen, Xiao-Hua Yu, Chang-Jian Yang, Xiao-Mei Shu, Mao-Qiang Tian   +8 more
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Functional Characterization of CaSpr2 in Jasmonate-Dependent Induced Defense Against Western Flower Thrips in Capsicum annuum [PDF]

Insects
Insect infestation poses a significant threat to global agriculture by impairing plant growth and reducing crop yields. The western flower thrip (WFT) causes substantial damage through both direct feeding and transmission of plant viruses.
Xi Chen, Shuo Lin, Tingting Linghu, Yun Yu, Heng Li, Yixin Chen, Hui Wei, Yong Chen   +7 more
doaj   +2 more sources

A rare presentation of CASPR2-associated Morvan syndrome overlapping with GM1-positive AMSAN: a case report [PDF]

Frontiers in Immunology
BackgroundMorvan syndrome is a rare autoimmune disorder characterized by peripheral nerve hyperexcitability with autonomic and central nervous system involvement, most commonly associated with antibodies against contactin-associated protein-like 2 ...
Yajing Wu, Yajing Wu, Xiaoli Tang, Tianyuan Guan, Jing Xu, Peiyuan Lv, Peiyuan Lv, Yanhong Dong, Yanhong Dong   +8 more
doaj   +2 more sources

Clinical spectrum of contactin-associated protein 2 autoimmune encephalitis in children

Frontiers in Neuroscience, 2023
ObjectiveAnti-contactin-associated protein 2 (CASPR2)-related autoimmune encephalitis (AE) is more common in adults than in children. Clinical understanding of anti-CASPR2-antibody (Ab)-related AE, diagnosis and treatment standards are lacking in ...
Wenjing Hu, Enhui Wang, Hongjun Fang, Li Li, Jurong Yi, Qingqing Liu, Wei Qing, Danni Guo, Qianqian Tan, Hongmei Liao   +9 more
doaj   +1 more source

Anti-contactin-associated protein-like 2 antibody-associated encephalitis in children: A case report and literature review

Frontiers in Pediatrics, 2022
BackgroundAnti-Contactin-associated protein-like 2 (CASPR2) antibody-associated encephalitis is a rare group of autoimmune diseases that causes extensive damage to the central and/or peripheral nervous system.Case presentationHere, we reported a case of ...
Qingyang Dou, Qingyang Dou, Renke Li, Xiaomei Shu   +3 more
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Clinical characteristics, long-term functional outcomes and relapse of anti-LGI1/Caspr2 encephalitis: a prospective cohort study in Western China

Therapeutic Advances in Neurological Disorders, 2022
Objective: To study the clinical characteristics of anti-leucine-rich glioma-inactivated 1 (LGI1) encephalitis and anti-contactin-associated protein-like 2 (Caspr2) encephalitis and to investigate factors associated with poor long-term neurological ...
Kundian Guo, Xu Liu, Jingfang Lin, Xue Gong, Aiqing Li, Yue Liu, Dong Zhou, Zhen Hong   +7 more
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In utero exposure to endogenous maternal polyclonal anti-Caspr2 antibody leads to behavioral abnormalities resembling autism spectrum disorder in male mice

Scientific Reports, 2020
The concept that exposure in utero to maternal anti-brain antibodies contributes to the development of autism spectrum disorders (ASD) has been entertained for over a decade. We determined that antibodies targeting Caspr2 are present at high frequency in
Ciara Bagnall-Moreau, Patricio T. Huerta, Davide Comoletti, Andrea La-Bella, Roseann Berlin, Chunfang Zhao, Bruce T. Volpe, Betty Diamond, Lior Brimberg   +8 more
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Differential impacts of Cntnap2 heterozygosity and Cntnap2 null homozygosity on axon and myelinated fiber development in mouse

Frontiers in Neuroscience, 2023
Over the last decade, a large variety of alterations of the Contactin Associated Protein 2 (CNTNAP2) gene, encoding Caspr2, have been identified in several neuronal disorders, including neurodevelopmental disorders and peripheral neuropathies.
Carmen Cifuentes-Diaz, Carmen Cifuentes-Diaz, Carmen Cifuentes-Diaz, Giorgia Canali, Giorgia Canali, Giorgia Canali, Marta Garcia, Marta Garcia, Marta Garcia, Mélanie Druart, Mélanie Druart, Mélanie Druart, Taylor Manett, Taylor Manett, Taylor Manett, Mythili Savariradjane, Mythili Savariradjane, Mythili Savariradjane, Camille Guillaume, Camille Guillaume, Camille Guillaume, Corentin Le Magueresse, Corentin Le Magueresse, Corentin Le Magueresse, Laurence Goutebroze, Laurence Goutebroze, Laurence Goutebroze   +26 more
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