Results 11 to 20 of about 3,617 (131)

Seronegative Morvan Syndrome Presenting With Agrypnia Excitata and Peripheral Nerve Hyperexcitability: A Phenotype-Supported Diagnostic and Therapeutic Approach in a Resource-Limited Setting. [PDF]

Clin Case Rep
ABSTRACT We report a 63‐year‐old Palestinian man with seronegative Morvan syndrome presenting with the complete clinical triad: continuous neuromyotonia with visible myokymia, severe insomnia consistent with agrypnia excitata phenotype (2–3 h/night; Insomnia Severity Index [ISI] 24/28, validated Arabic version), tachycardia (118 bpm), profuse ...
Taha HM, Taha KH.
europepmc   +2 more sources

Caspr2 antibodies in herpes simplex encephalitis: an extension of the spectrum of virus induced autoimmunity? – A case report

BMC Neurology, 2022
Background Post herpes simplex virus (HSV) autoimmune encephalitis has been reported mainly in association with NMDA receptor antibodies, however, never with Caspr2 antibodies.
Klaus Berek, Ronny Beer, Astrid Grams, Raimund Helbok, Anna Lindner, Bettina Pfausler, Alois Schiefecker, Florian Deisenhammer, Harald Hegen   +8 more
doaj   +1 more source

Inhibitory axons are targeted in hippocampal cell culture by anti-Caspr2 autoantibodies associated with limbic encephalitis

Frontiers in Cellular Neuroscience, 2015
Contactin-associated protein-like 2 (Caspr2), also known as CNTNAP2, is a cell adhesion molecule that clusters voltage-gated potassium channels (Kv1.1/1.2) at the juxtaparanodes of myelinated axons and may regulate axonal excitability.
Delphine ePinatel, Bruno eHivert, José eBoucraut, Margaux eSaint-Martin, Margaux eSaint-Martin, Margaux eSaint-Martin, Veronique eRogemond, Veronique eRogemond, Veronique eRogemond, Lida eZoupi, Domna eKaragogeos, Jerome eHonnorat, Jerome eHonnorat, Jerome eHonnorat, Catherine eFaivre-Sarrailh   +14 more
doaj   +1 more source

Case report: Autoimmune encephalitis associated with anti-CASPR2 antibody mimicking cerebral infarction

Frontiers in Immunology, 2023
Autoimmune encephalitis associated with antibody against contactin-associated protein-like 2 (CASPR2) varies in its clinical presentation. The disease is difficult to distinguish from some other conditions without testing for anti-CASPR2 antibody in ...
Ziqi Chen, Jing Tang
doaj   +1 more source

Clinical Features and Outcomes in Pediatric Autoimmune Encephalitis Associated With CASPR2 Antibody

Frontiers in Pediatrics, 2021
Background: Contactin-associated protein-like 2 (CASPR2) neurological autoimmunity has been associated with various clinical syndromes involving central and peripheral nervous system.
Chengbing Tan, Chengbing Tan, Yan Jiang, Yan Jiang, Min Zhong, Min Zhong, Yue Hu, Yue Hu, Siqi Hong, Siqi Hong, Xiujuan Li, Xiujuan Li, Li Jiang, Li Jiang   +13 more
doaj   +1 more source

Contactin-associated protein 2 autoantibodies can be associated with multifocal motor-like neuropathy: a case report

Therapeutic Advances in Neurological Disorders, 2023
Autoantibodies against contactin-associated protein 2 (CASPR2) are usually associated with autoimmune encephalitis and neuromyotonia. Their association with inflammatory neuropathies has been described in case reports albeit all with distal symmetric ...
Louisa Müller-Miny, Raoul Sauer, Andreas Schulte-Mecklenbeck, Catharina C. Gross, Stjepana Kovac, Matthias Schilling, Carolin Beuker, Heinz Wiendl, Gerd Meyer zu Hörste   +8 more
doaj   +1 more source

A new Patient-Reported Outcome Scale to assess autoimmune Encephalitis: PROSE. [PDF]

Ann Neurol
Objective Autoimmune encephalitis (AIE) has long‐lasting effects. Generic clinical assessment‐scales insufficiently capture disease‐specific sequelae. Patient‐reported outcome measures (PROMs) assess outcomes important to patients, ensuring relevance in the clinic and trials.
Brenner J, Crijnen YS, Kulderij I, Olijslagers SHC, Ruhe CJ, Tolido AAG, Kersten LP, Verkoelen JCP, Kret CN, Thomassen B, van Wijnen FI, de Vries JM, Bienfait TM, Brand T, Kerstens J, van Steenhoven RW, Bastiaansen AEM, de Bruijn MAAM, van Sonderen A, Veenbergen S, Easton A, Sillevis Smitt PAE, van den Berg E, Mandarakas M, Titulaer MJ.   +24 more
europepmc   +2 more sources

Stereotactically Injected Kv1.2 and CASPR2 Antisera Cause Differential Effects on CA1 Synaptic and Cellular Excitability, but Both Enhance the Vulnerability to Pro-epileptic Conditions

Frontiers in Synaptic Neuroscience, 2020
PurposeWe present a case of voltage-gated potassium channel (VGKC) complex antibody-positive limbic encephalitis (LE) harboring autoantibodies against Kv1.2.
Timo Kirschstein, Timo Kirschstein, Timo Kirschstein, Erika Sadkiewicz, Gerda Hund-Göschel, Juliane Becker, Xiati Guli, Steffen Müller, Marco Rohde, Dora-Charlotte Hübner, Hannes Brehme, Stephan Kolbaske, Katrin Porath, Tina Sellmann, Annette Großmann, Matthias Wittstock, Steffen Syrbe, Alexander Storch, Alexander Storch, Rüdiger Köhling, Rüdiger Köhling   +20 more
doaj   +1 more source

Anti-CASPR2 antibody-associated autoimmune encephalitis： a case report

Sichuan jingshen weisheng, 2023
This paper elaborated a case of an elderly patient with anti-contactin-associated protein-like 2 （CASPR2） antibody-associated autoimmune encephalitis.
Xing Xin, Zhou Bo
doaj   +1 more source

Espectro clínico y valor diagnóstico de los anticuerpos contra el complejo proteico asociado a canales de potasio

Neurología, 2015
Resumen: Introducción: Los anticuerpos contra un complejo proteico que incluye a los canales de potasio dependientes de voltaje (CKVD) se han descrito en pacientes con encefalitis límbica, hiperexcitabilidad del nervio periférico, síndrome de Morvan ...
M.T. Montojo, M. Petit-Pedrol, F. Graus, J. Dalmau   +3 more
doaj   +1 more source