Results 41 to 50 of about 3,052 (179)

Development of a physiologically‐based pharmacokinetic model for Ritonavir characterizing exposure and drug interaction potential at both acute and steady‐state conditions

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 523-539, March 2025.
Abstract Ritonavir (RTV) is a potent CYP3A inhibitor that is widely used as a pharmacokinetic (PK) enhancer to increase exposure to select protease inhibitors. However, as a strong and complex perpetrator of CYP3A interactions, RTV can also enhance the exposure of other co‐administered CYP3A substrates, potentially causing toxicity.
Lien Thi Ngo, Woojin Jung, Tham Thi Bui, Hwi‐yeol Yun, Jung‐woo Chae, Jeremiah D. Momper   +5 more
wiley   +1 more source

El veinticinco aniversario de la Bluefields Indian & Caribbean University (BICU)

Wani
En diciembre de 2015, el Consejo Universitario aprobó el plan de actividades desarrollarse durante el año 2016 para celebrar el 25 aniversario de existencia de la universidad de las comunidades de la costa caribe nicaragüense. Durante cinco meses hemos
Gustavo Castro Jo
doaj   +1 more source

Transcriptomics Unveil Dsx1 as a Critical Regulator in Sexual Dimorphism of Crustaceans

Integrative Zoology, EarlyView.
Sexually dimorphic traits are involved in reproductive competition and are shaped by sex‐biased gene expression. This study identifies Dsx1 as a key male‐biased gene in Morinoia aosen and demonstrates through RNA interference that its disruption feminizes male‐specific T3 leg structures.
Yan Tong, Wenpei Xin, Zeyu Liu, Yami Zheng, Mengyi Huang, Hongguang Liu, Decai Lu, Wei Peng, Zhonge Hou   +8 more
wiley   +1 more source

Rescaling the Developmental State: Competitive Shrinkage Governance and the Spatial Restructuring of Higher Education in South Korea

Asia Pacific Viewpoint, EarlyView.
ABSTRACT Against the backdrop of sustained demographic contraction across the Asia‐Pacific, the developmental state (DS) paradigm, long premised on growth, faces profound challenges. While existing research on shrinking regions focuses on urban planning, little attention has been paid to how the state restructures its spatial power under contraction ...
Li Mingfeng
wiley   +1 more source

Exact bound state solutions of the radial Schrödinger equation for the Coulomb potential by conformable Nikiforov–Uvarov approach

Open Physics
In this work, we investigate the use of the conformable Nikiforov–Uvarov (CNU) method to solve the radial Schrödinger equation exactly for the Coulomb potential.
Jaradat Emad K., Alomari Omar, Tarawneh Mariam M., Jaradat Omar K.   +3 more
doaj   +1 more source

Resilience of Korean breast cancer survivors within family relationships: A qualitative study

Family Relations, EarlyView.
ABSTRACT Objective To explore South Korean breast cancer survivors' perspectives on family experiences during treatment and examine how family dynamics contribute to resilience. Background Limited research has addressed how South Korean women with breast cancer perceive culturally shaped resilience within the context of family conflicts and role ...
Mi Sook Jung, Myoungock Jang
wiley   +1 more source

Relationships between chick vocalizations and parental absence in Kentish Plovers

Ibis, EarlyView.
Chick calls within bird species vary greatly, often in relation to whether parents are present. We studied chick calls in a nidifugous shorebird, the Kentish Plover Anarhynchus alexandrinus, in three circumstances—(1) on the nest with parental presence; (2) on the nest with parental absence; and (3) out‐of‐nest with human observer presence—and ...
Dong‐Yun Lee, Edward H. Miller, Ju‐Hyun Lee, Woo‐Yuel Kim, Seung‐Jun Oh, Ha‐Cheol Sung   +5 more
wiley   +1 more source

The CnuK9E H-NS complex antagonizes DNA binding of DicA and leads to temperature-dependent filamentous growth in E. coli. [PDF]

PLoS ONE, 2012
Cnu (an OriC-binding nucleoid protein) associates with H-NS. A variant of Cnu was identified as a key factor for filamentous growth of a wild-type Escherichia coli strain at 37°C.
Sang Hoon Yun, Sang Chun Ji, Heung Jin Jeon, Xun Wang, Si Wouk Kim, Geunu Bak, Younghoon Lee, Heon M Lim   +7 more
doaj   +1 more source

Quantitative Analysis of Individual‐ and Group‐Level Viral Shedding Reveals Transmission Dynamics of Viral Hemorrhagic Septicemia Virus (VHSV) in Olive Flounder (Paralichthys olivaceus)

Journal of Fish Diseases, EarlyView.
ABSTRACT Viral hemorrhagic septicemia virus (VHSV) is a highly pathogenic rhabdovirus that primarily spreads through horizontal transmission. Characterizing viral shedding dynamics is therefore critical for understanding its epidemiology and improving disease control strategies in aquaculture.
Su‐Young Yoon, Yo‐Seb Jang, Myung‐Joo Oh   +2 more
wiley   +1 more source

Phloridzin Mitigates Aging‐Associated Periodontitis by Restraining Inflammatory Cell Death

Journal of Periodontal Research, EarlyView.
Phloridzin attenuated oxidative stressinduced senescence, inflammatory responses, and osteogenic dysfunction in HPDLCs. In an aging‐associated experimental periodontitis model, phloridzin alleviated alveolar bone loss, suggesting its potential to maintain periodontal tissue integrity under aging‐related inflammatory conditions.
Da Eun Lee, Eun‐Nam Kim, Gil‐Saeng Jeong   +2 more
wiley   +1 more source