Results 221 to 230 of about 72,857 (290)

The evaluation of copy number variants in an unselected population of patients with inherited cardiac conditions: the INTERACTION study. [PDF]

Europace
Corona G, Simona M, Maria G, Martina M, Carmela F, Silvia M, Italia L, Floriana B, Luigi A, Stefania P, Luisa C, Andrea F, Valentina A, Rossana M, Francesca G, Ivan L, Mara G, Valeria N.   +17 more
europepmc   +1 more source

PTEN homozygous deletion is a negative prognostic factor in tumor treating fields‐treated glioblastoma, IDH wildtype patients

Brain Pathology, EarlyView.
In a molecularly confirmed cohort of 64 newly diagnosed, TTFields‐treated glioblastomas, IDH‐wildtype, homozygous PTEN deletion was associated with markedly shorter overall survival (368 vs. 603 days) and remained an independent adverse prognostic factor.
Jakob Nückles, Claudius Jelgersma, Christin Siewert, Brendan Osberg, Simone Schmid, Arend Koch, Eilís Perez, Daniel Teichmann, Martin Misch, Anna‐Gila Karbe, Susanne Ukrow, Patrick N. Harter, Ruth M. Stassart, Peter Vajkoczy, Julia Onken, David Capper   +15 more
wiley   +1 more source

A stratified urine-based molecular diagnostic and prognostic model for non-muscle-invasive bladder cancer management. [PDF]

BMC Cancer
Yi L, Ma Z, Zhang J, Zhan Y, Xiao H, Dai K, Liu Y, Gao Y, Yang X, Cao D, Xu D, Huang H.   +11 more
europepmc   +1 more source

A Three‐Dimensional Culture–Drug Sensitivity Test Predicts MDM2 Inhibitor–Sensitivity in SMARCB1/INI1‐Deficient Tumors

Cancer Science, EarlyView.
This study aimed to determine whether personalized selection of effective drugs for SMARCB1/INI1‐deficient tumors is feasible using in vitro drug sensitivity profiling. Drug sensitivity was assessed using a short‐term collagen gel–embedded three‐dimensional drug sensitivity test (3D‐DST) in tumors derived from SMARCB1/INI1‐deficient tumor cell line ...
Hiroaki Goto, Chiyoko Nishime, Takashi Ohtsu, Mieko Ito, Maiko Sagisaka, Takuya Naruto, Norihiko Kitagawa, Mio Tanaka, Masakatsu Yanagimachi, Yukihiko Hiroshima, Junko Takita, Yasuhide Hayashi, Yohei Miyagi   +12 more
wiley   +1 more source

Detection and evaluation of copy number variation using both linked-read and short-read sequencing in New Zealand dairy cattle. [PDF]

Front Genet
Wang Y, Nugroho T, Johnson TJJ, Couldrey C, Harris BL.   +4 more
europepmc   +1 more source

Genetic Evolution in BRCA1‐Associated Breast Cancer Reveals Early Driver Mutations Shaping Tumor Features and Prognosis

Cancer Science, EarlyView.
Multi‐region sequencing of 57 BRCA1‐associated breast cancers identified TP53 as the dominant initial driver, defining a triple‐negative subgroup with biallelic BRCA1 loss and elevated genomic instability. TP53 truncating mutations were enriched in BRCA1 carriers and linked to reduced HRD, EMT activation, and a trend toward worse survival.
Li Hu, Zhongwu Li, Qiting Wan, Xingyu Liao, Yaxin Zhang, Qian Liu, Xinyun Ding, Hua Meng, Yifan Wu, Jie Sun, Juan Zhang, Lu Yao, Ye Xu, Yuntao Xie   +13 more
wiley   +1 more source

Intravitreal Dexamethasone Implant in Punctate Inner Choroidopathy: Clinical Indications and Outcomes in a Real-World Case Series. [PDF]

Ophthalmol Ther
Capobianco M, Rissotto F, Marzano C, Trinco A, Del Fabbro S, Bandello F, Invernizzi A, Miserocchi E, Cicinelli MV.   +8 more
europepmc   +1 more source

Endothelial TGFβ signaling modulates choroidal neovascularization severity via myeloid-endothelial cell interaction. [PDF]

Front Immunol
Schlecht A, Müllerbauer L, Fitz K, Brunne B, Hofmann N, Müller C, Hillenkamp J, Ergün S, Neueder A, Braunger BM.   +9 more
europepmc   +1 more source

Linoleic acid metabolic reprogramming is linked to immunometabolic remodeling and post-transplant recurrence risk in hepatocellular carcinoma. [PDF]

Front Immunol
Zhang R, Zhang A, Gao T, Zhang C, Liu Y, Liu L.   +5 more
europepmc   +1 more source