Results 221 to 230 of about 75,040 (259)

Mononuclear phagocyte-specific cGAS/STING targeting suppresses experimental choroidal neovascularization. [PDF]

JCI Insight
Shi L, Cherukaraveedu D, Cho H, Ri K, Zhou L, Cao Y, Kale N, Xu Z, Liyanage W, Kannan RM, Duh EJ.   +10 more
europepmc   +1 more source

A Multicellular Coordinated Network Driving Lymphovascular Space Invasion in Endometrioid Endometrial Carcinoma

Cell Proliferation, EarlyView.
Single‐cell and spatial profiling reveal that lymphovascular space invasion in endometrioid endometrial carcinoma is driven by coordinated interactions among metastatic epithelium, fibroblasts, immune cells, and endothelium. This multicellular network promotes matrix remodelling, angiogenesis, and immune evasion, forming a pro‐metastatic niche that ...
Wendi Guo, Tianxiang Liu, Runling Ren, Na Li, Wenwen Zhang, Jingwen Si, Yongjun Piao, Yuanjing Hu   +7 more
wiley   +1 more source

Diagnostic Yield and Clinical Utility of Chromosomal Microarray Analysis (CMA) in Children With Developmental Delay, Intellectual Disability, and Autism Spectrum Disorder: A Systematic Review. [PDF]

Cureus
Abdelgayoum Ahmed MO, Khiri Ahmed EA, Ahmed Elnour SE, Mohamed Elamin AM, Mohamed Elamin HE, Mohamed Elawad SAO, Elbakry Abdelmahdy NE, Alquhazi AS.   +7 more
europepmc   +1 more source

SKY92 Identifies High‐Risk Newly Diagnosed Multiple Myeloma With Inferior Progression‐Free Survival and Implicates NUF2 as a Candidate Driver

European Journal of Haematology, EarlyView.
ABSTRACT Objectives To determine the prevalence and prognostic significance of the SKY92 gene‐expression signature, evaluate minimal/measurable residual disease (MRD), and identify molecular drivers of high‐risk disease in transplant‐eligible newly diagnosed multiple myeloma (TE‐NDMM) patients in the Republic of Ireland.
Roisin M. McAvera, Izabela Cymer, John Quinn, Phillip T. Murphy, Patrick Thornton, Niamh McAuley, Harmony Black, Omar Abdelzaher, Catherine Duane, Tatiana Cichocka, Eva Szegezdi, Meegahage Perera, Gerard M. Crotty, Michelle Connolly, Aileen Walsh, Ruth Clifford, Janusz Krawczyk, Teresa Meenaghan, Vitaliy Mykytiv, Ezzat Elhassadi, Mark Coyne, Robert J. Cummins, Rowan Kuiper, Michael O'Dwyer, Siobhan V. Glavey   +24 more
wiley   +1 more source

Xp21 contiguous gene deletion syndrome presenting as congenital adrenal hypoplasia: molecular diagnosis and clinical re-evaluation of a pedigree. [PDF]

Front Endocrinol (Lausanne)
Zhang D, Li W, Li M, Lu Y, Ning S, Liang X, Xie Y, Qin Y.   +7 more
europepmc   +1 more source

A guide to host genetic determinants of female microbiome composition across distinct anatomical niches

The FEBS Journal, EarlyView.
Host genetic variation in immune regulation and cell signalling genes was associated with microbiome composition across vaginal, gut, oral and skin sites, while associations involving metabolic function, epithelial barrier integrity and hormonal processes were more site‐specific. Overall, our findings indicate that host genetic variation contributes to
Isabella Margaret Davidson, Elham Nikbakht, Hayley O'Neill, Larisa Margaret Haupt, Paul Joseph Dunn   +4 more
wiley   +1 more source

Genome variation of Sporothrix schenckii and Sporothrix brasiliensis. [PDF]

PLoS Negl Trop Dis
Bagal UR, Santos AR, Paes RA, de Brito Alves LG, Chamorro LR, Parnell LA, Brunelli JP, Chow NA, Pohl J, Brito VR, Poester VR, Spruijtenburg B, Fernandes L, Barker BM, Stajich JE, Felipe MS, Rhodes J, Xavier MO, Matute DR, Zancope R, Teixeira MM.   +20 more
europepmc   +1 more source

NFE2L2‐mutated urothelial carcinomas frequently show concomitant myxoid and squamous features and have high PD‐L1 expression

Histopathology, EarlyView.
Aims NFE2L2 encodes the transcription factor, NRF2, which is a regulator of cellular oxidative stress responses and metabolic homeostasis. NFE2L2 alterations are implicated in multiple cancers, with significant study in thoracic oncology, with an adverse prognosis, aggressive behaviour, metabolic reprogramming and diminished responses to chemotherapy ...
Dane Wuori, Alexander Guzzetta, Melissa Y. Tjota, Peng Wang, Tatjana Antic, Jung Woo Kwon   +5 more
wiley   +1 more source

Copy number variation analysis of cerebrospinal fluid metagenomic next-generation sequencing data in assisting the diagnosis of pediatric brain tumors. [PDF]

Pediatr Investig
Ren C, Zhuo X, Yang X, Yao X, Gong S, Xiong H, Fang F, Zhang W.   +7 more
europepmc   +1 more source

Clinicopathological and molecular comparison of eosinophilic solid and cystic renal cell carcinoma and TFEB‐amplified renal cell carcinoma: a comprehensive study of 15 cases

Histopathology, EarlyView.
This study supports the need for ancillary testing to diagnose ESC‐RCC versus TFEB‐amplified RCC, as neither morphology nor immunohistochemistry is sufficiently specific to distinguish these entities. The underlying molecular drivers in each tumour are pathogenic TSC1 or TSC2 gene variants in ESC‐RCC and TFEB gene amplification in TFEB‐amplified RCC ...
Hayley Zullow, Melissa Y. Tjota, Jung Woo Kwon, Tatjana Antic   +3 more
wiley   +1 more source