Results 51 to 60 of about 817,400 (198)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Simultaneous Acute Appendicitis and Isolated Common Iliac Artery Aneurysm: A Case Report

Clinical Case Reports
This case report presents the rare simultaneous occurrence of acute appendicitis and a large right common iliac artery aneurysm in a 69‐year‐old male with a history of diabetes and hypertension.
Meghdad Ghasemi Gorji, Fardin Karbakhsh Ravari, Ali Rafiei, Aisa Iranmanesh, Maral Ebrahimi Alamdari   +4 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Concurrent Psoriasis and Dermatomyositis: Retrospective Analysis and Literature Review

JEADV Clinical Practice
Background Psoriasis (PsO) and dermatomyositis (DM) are both autoimmune‐mediated, inflammatory conditions. The concurrence of PsO and DM is rare, and literature on their relationship remains limited.
Emily R. Gordon, Karishma S. Shah, Sidharth Chand, Bonnie Lee, Janellen Smith, Michelle S. Min   +5 more
doaj   +1 more source

Earth microbial co-occurrence network reveals interconnection pattern across microbiomes

Microbiome, 2020
Background Microbial interactions shape the structure and function of microbial communities; microbial co-occurrence networks in specific environments have been widely developed to explore these complex systems, but their interconnection pattern across ...
Bin Ma, Yiling Wang, Shudi Ye, Shan Liu, Erinne Stirling, Jack A. Gilbert, Karoline Faust, Rob Knight, Janet K. Jansson, Cesar Cardona, Lisa Röttjers, Jianming Xu   +11 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Advancing single‐species abundance models: Robust models for predicting abundance using co‐occurrence from communities

Ecosphere
Accurate estimates of abundance are crucial for successful conservation and management. However, gathering abundance data is costly. Species abundance models (SAMs) are increasingly used to predict variation in abundance for resource management for ...
Aliénor Stahl, Eric J. Pedersen, Pedro R. Peres‐Neto   +2 more
doaj   +1 more source

Duck species co‐occurrence in hunter daily bags

Wildlife Society Bulletin, 2015
As multi‐species harvest management gains support among waterfowl managers, increased understanding of duck species relationships during harvest is needed. We used U.S. Fish and Wildlife Service's Parts Collection Survey data from 2002 to 2011 to develop
Matthew T. Haugen, Mark P. Vrtiska, Larkin A. Powell   +2 more
doaj   +1 more source