Results 101 to 110 of about 5,986,469 (304)

The influence of extracorporeal circulation on EV1000 monitor hemodynamic parameters at two sites of intravenous cold saline injection

Fujita Medical Journal, 2016
Objective: Previous studies have suggested that transpulmonary thermodilution (TPTD) measurements are influenced by extracorporeal circulation methods, such as blood purification.
Toshikazu Sakai, Yoshitaka Hara, Yu Kato, Tomoyuki Nakamura, Yasuyo Shimomura, Takahiro Kawaji, Yasuyoshi Kurimoto, Mariko Nagata, Seiko Hayakawa, Hidefumi Komura, Chizuru Yamashita, Junpei Shibata, Kazuhiro Moriyama, Osamu Nishida   +13 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Co-circulation of distinct shrew-borne hantaviruses in the far east of Russia

Virus Research, 2019
Insectivores are the new emerging reservoir of hantaviruses. Here, we describe Lena virus (LENV), a novel hantavirus harbored by the Laxmann`s shrew (Sorex caecutiens), which is also the host of Artybash virus (ARTV). Genetic analysis of the complete genomic sequence shows that LENV is in distant relation to ARTV and other Sorex-borne hantaviruses ...
Liudmila N, Yashina, Mikhail Yu, Kartashov, Wen, Wang, Kun, Li, Nina I, Zdanovskaya, Leonid I, Ivanov, Yong-Zhen, Zhang   +6 more
openaire   +2 more sources

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Co-Circulating Monkeypox and Swinepox Viruses, Democratic Republic of the Congo, 2022

Emerging Infectious Diseases
In September 2022, deaths of pigs manifesting pox-like lesions caused by swinepox virus were reported in Tshuapa Province, Democratic Republic of the Congo. Two human mpox cases were found concurrently in the surrounding community. Specific diagnostics and robust sequencing are needed to characterize multiple poxviruses and prevent potential poxvirus ...
Kalonji, Thierry, Malembi, Emile, Matela, Jean Paul, Likafi, Toutou, Kinganda-Lusamaki, Eddy, Vakaniaki, Emmanuel Hasivirwe, Hoff, Nicole A., Aziza, Amuri, Muyembe, Francisca, Kabamba, Joelle, Cooreman, Tine, Nguete, Beatrice, Witte, Danae, Ayouba, Ahidjo, Fernandez-Nunez, Nicolas, Roge, Stijn, Peeters, Martine, Merritt, Sydney, Ahuka-Mundeke, Steve, Delaporte, Eric, Pukuta, Elisabeth, Marien, Joachim, Bangwen, Eugene, Lakin, Steven, Lewis, Charles, Doty, Jeffrey B., Liesenborghs, Laurens, Hensley, Lisa E., Mccollum, Andrea, Rimoin, Anne W., Muyembe-Tamfum, Jean Jacques, Shongo, Robert, Kaba, Didine, Mbala-Kingebeni, Placide   +33 more
openaire   +7 more sources

Construction of flaxseed polyphenol nanolipid emulsions as edible coatings and their application in shelf life extension of spiced beef

Food Chemistry: X
Flaxseed polyphenols exhibited antibacterial and antioxidant properties; however, their poor solubility and stability limited their application in food products. Incorporation into nano-emulsions improved their dissolution and encapsulation.
Yan Ma, Nan Wang, Xiaoyong Liu, Xiangjie Ma, Shaohua Meng, Jiansheng Zhao, Jingjing Chen, Lianjun Song, Mingwu Qiao, Xianqing Huang   +9 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Co-circulating mumps lineages at multiple geographic scales

, 2018
Abstract Despite widespread vaccination, eleven thousand mumps cases were reported in the United States (US) in 2016–17, including hundreds in Massachusetts, primarily in college settings. We generated 203 whole genome mumps virus (MuV) sequences from Massachusetts and 15 other states to understand the dynamics of mumps spread locally ...
Wohl, Shirlee, Metsky, Hayden C., Schaffner, Stephen F., Piantadosi, Anne, Burns, Meagan, Lewnard, Joseph A., Chak, Bridget, Krasilnikova, Lydia A., Siddle, Katherine J., Matranga, Christian B., Bankamp, Bettina, Hennigan, Scott, Sabina, Brandon, Byrne, Elizabeth H., McNall, Rebecca J., Park, Daniel J., Gharib, Soheyla, Fitzgerald, Susan, Barriera, Paul, Fleming, Stephen, Lett, Susan, Rota, Paul A., Madoff, Lawrence C., MacInnis, Bronwyn L., Yozwiak, Nathan L., Smole, Sandra, Grad, Yonatan H., Sabeti, Pardis C.   +27 more
openaire   +2 more sources