Results 81 to 90 of about 6,704,341 (266)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

The Business of Co-creation and the Co-creation of Business

, 2009
Afhandlingen ”The Business of Co-creation – and the Co-creation of Business” handler om, hvorledes danske produktionsvirksomheder tackler globaliserings udfordringer og muligheder gennem udviklingen af nye former for sam-skabende arbejdsorganiseringspraksisser. Studiet udforsker hvordan disse arbejdsorganiseringspraksisser bliver sam-skabt, (og hvad de
openaire   +3 more sources

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The Protective Effects of Membrane‐Separated Ripe Pu‐Erh Tea Extracts Against Chronic Alcoholic Liver Injury

Food Frontiers
Excessive alcohol consumption in contemporary society induces alcoholic liver disease (ALD). Previous laboratory studies demonstrated hepatoprotective and gut microbiota–modulating effects of ripe Pu‐erh tea.
Sibo Zhao, Jielin Jiang, Yan Liu, Mianhong Xu, Rui Yang, Zhi Yang, Jilin Xie, Zhanggui Ding, Liyong Luo, Liang Zeng   +9 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Modelling of high frequency bearing voltage for dual‐winding permanent magnet synchronous generators

IET Electric Power Applications
The modelling and analysis of high‐frequency bearing voltage are of great significance to the assessment and mitigation of the electrical erosion risk in wind power systems.
Zhihao Li, Ruifang Liu, Liangliang Zhang, Weili Li, Shulin Li, Xin Huang   +5 more
doaj   +1 more source

Effect of cultivation feed diet using local food processing by-products on the growth and flavor factor in the Malabar grouper Epinephelus malabaricus

Frontiers in Aquaculture
IntroductionThis study investigated the use of locally sourced food processing by-products to formulate sustainable aquaculture feed in alignment with circular economy principles.MethodsAn experimental diet (Food Waste Diet; FW-D) was formulated using 50%
Makoto Takahashi, Shingo Udagawa, Chihiro Yamauchi, Yoshimi Imura, Taekyoung Seong, Akihiro Takemura   +5 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Modelling and suppression of bearing voltage of wind turbine permanent magnet synchronous generators

IET Electric Power Applications
The problem of bearing current is common in wind power generation system, which leads to the attenuation of generator life and great economic losses. Bearing voltage of a 5.5 MW wind‐turbine permanent magnet synchronous generator is studied.
Lei Jia, Ruifang Liu, Zhihao Li, Shulin Li, Xin Huang   +4 more
doaj   +1 more source