Results 121 to 130 of about 1,077,021 (339)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
The Jinja Stakeholders' Workshop, February 21st -23rd, 2001 [PDF]
, 2000 This book section is a review of a workshop, the one held at Jinja in Uganda, which aimed to assess the potential local stakeholders within the frame of the co-management of Lake Victoria's ...
Atai, A. +4 more
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Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Incorporating economic, social and environmental factors into a decision model for sustainable management of natural resources : a case study of the Ningaloo coast, Western Australia : a thesis presented in partial fulfilment of the requirements for the degree of Master of Applied Economics at Massey University [PDF]
, 2003 There is growing demand for many of Australia's coastal areas to be conserved and retained in their natural state. The reconciliation of competing demands; such as residential, industrial, recreation, conservation and tourism; in a manner that ensures ...
Longworth, Natasha Julie
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Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Enhancing governance in fisheries management in southeast Asia towards 2020: issues and perspectives [PDF]
This is a keynote address at the ASEAN-SEAFDEC conference on Sustainable Fisheries for Food Security Towards 2020, Fish for the People 2020: Adaptation to a Changing Environment.
Viswanathan, K. Kuperan
core +1 more source
Catch Shares in Action: Mexican Vigía Chico Cooperative Spiny Lobster Territorial Use Rights for Fishing Program [PDF]
, 2013 The Mexican Pescadores de Vigía Chico Cooperative is a group-allocated, area-based catch share that manages the Punta Allen spiny lobster fishery. The catch share, or Territorial Use Rights for Fishing (TURF) program, includes a number of special design ...
Erica Cunningham
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Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
When co-management fails: a review of theory and lessons learned from reservoir fisheries in dry-zone of Sri Lanka [PDF]
Over recent decades co-management has become an increasingly popular form of governance reform in many developing countries. Viewed as a means of promoting sustainable and equitable management of natural resources, it has seen wide application in small ...
Murray, F.
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