Results 71 to 80 of about 10,517,441 (314)
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Settlements of the future [PDF]
Urbani Izziv, 2002 Current ongoing societal processes allow me to say that all humanity must foresee the great opportunity to change direction from market driven development to human scale sustainable development as the only way to achieve whole scale growth.
Domen Zupančič
doaj
Wildlife Conservation and Management in Kenya: Towards a Co-management Approach [PDF]
The co-management approach of managing natural resources has increasingly become popular among conservationists and development practitioners since it overcomes the shortcomings of both the centralised management and community-based approaches that ...
John Mburu
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The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Water Alternatives, 2018 This paper assesses a case of co-management of groundwater between the state of Texas, pushing for the rationalisation of groundwater management, and local (mainly farming) communities organised in Groundwater Conservation Districts (GCDs), which are ...
Alvar Closas , François Molle
doaj
Desenvolvimento e Meio Ambiente, 2016 The Brazilian coastal zone is singular by its historical socioeconomic importance and natural richness, where highly polluting activities coexists with valuable environmental resources.
Carlyle Torres Bezerra de Menezes +3 more
doaj +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Role of market microstructure in the relationship between market co-movement and market efficiency [PDF]
, 2012 viii, 66 leaves ; 29 cmThis study examines the effects of changes in stock market microstructure on internal market efficiency and explores the relations among internal market efficiency, market co-movement and cross-market efficiency using evidence from
Zhang, Xiaofei +1 more
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