Results 81 to 90 of about 14,311,182 (307)
Desenvolvimento e Meio Ambiente, 2016 The Brazilian coastal zone is singular by its historical socioeconomic importance and natural richness, where highly polluting activities coexists with valuable environmental resources.
Carlyle Torres Bezerra de Menezes +3 more
doaj +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Wildlife Conservation and Management in Kenya: Towards a Co-management Approach [PDF]
The co-management approach of managing natural resources has increasingly become popular among conservationists and development practitioners since it overcomes the shortcomings of both the centralised management and community-based approaches that ...
John Mburu
core
Co-designing the knowledge management model [PDF]
, 2020 This work-in-progress study reviews co-designing processes through the lens of possibility-driven design (PDD). A knowledge management model (KMM) is co-designed by facilitating the development work of senior and regional innovation actors who share ...
Tamminen, P. +2 more
core
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Letterbook of Robert Brooks and Co., 1872 July 12-1876 July 7 [manuscript].
, 1872 Manuscript reference no.: MS 2381.; Single volume, with letters on numbered leaves 87-499 (tissue paper), preceded by an index of recipients of letters on lined white paper. Some leaves unused; leaves 451, 454-455 omitted from foliation.
Robert Brooks and Co.
core
Conservation & Society, 2012 Forest tenure reform has opened economic and livelihood opportunities for community forestry management through the devolution of management rights under broader decentralisation reforms.
Peter Cronkleton +2 more
doaj +1 more source