Results 131 to 140 of about 17,311 (265)

Diagnoses of double heterozygous NF1 variants and dual RASopathy. [PDF]

Mol Cell Pediatr
Angelova-Toshkina D, Schanze D, Vaassen P, Frühwald MC, Rosenbaum T, Zenker M, Kuhlen M.   +6 more
europepmc   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Effects of Ethanol-Gasoline Blending on Combustion, Performance, and Emissions of a Spark Ignition Engine: An Experimental and Detailed Chemistry-Based Numerical Study. [PDF]

ACS Omega
Khedr AM, Ismael MA, El-Adawy M, Elserfy K, Abdelhafez A, Habib MA, Nemitallah MA.   +6 more
europepmc   +1 more source

Research Progress on Liquid CO₂ Phase-Transition Blasting Technology

Academic Journal of Science and Technology
Liquid CO₂ phase-transition blasting, as an environmentally friendly and green rock-breaking technology, offers advantages such as high rock-breaking efficiency, low vibration, and no pollution. In recent years, it has become a hot research topic in the field of rock fragmentation and excavation, with rapid development.
openaire   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Integrating RSM and NSGA-III for Multiobjective Optimization of a Diesel/Methanol Dual-Fuel Engine Performance and Emissions. [PDF]

ACS Omega
Huang F, Wang H, Wan M, Lei J.
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

From Spatial Epigenomes to Clinical Diagnostics: Integrative Methylomics Across Scales and Modalities. [PDF]

Int J Mol Sci
Kinzhebay A, Zhanymbetova A, Yerkos A, Zhetpisbay Z, Imanbek R, Salybekov AA.   +5 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Within-host diversity and phased variant analysis reveal structures and recombination of Helicobacter pylori subpopulations in stomach. [PDF]

Gigascience
Zhang X, Liu H, Xu S, Zhang S, Yang T, Lei Z, Xu W, Bo X, Yang C, Ni M.   +9 more
europepmc   +1 more source