Results 121 to 130 of about 3,133,433 (280)
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Circular Agricultural SystemsConcrete structures are some of the largest constructions in human civilization. Their manufacture releases CO2 into atmosphere, which is partially readsorbed by standing structures, and further release occurs when they are demolished.
Douglas A. Schaefer +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Influence of CO2 with impurities on dissolution law of sandstone
Youqi dizhi yu caishouluThe CO2 captured from the flue gas of coal-fired power plants usually contains other gases such as nitrogen oxides， sulfur oxides， and O2. These gases may threaten safe CO2 sequestration after they are injected with CO2 into formation.
JI Zemin +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Economics and Business ReviewThis study presents a comprehensive analysis of the relationship between economic growth and CO₂ emissions in the European Union, with a particular focus on the Environmental Kuznets Curve (EKC) hypothesis.
Suproń Błażej
doaj +1 more source
Fueling the future: Innovating the path to carbon-neutral skies with CO2-to-aviation fuel
Carbon FutureConsidering the increasing concerns regarding climate change, a fundamental transformation in global energy policies is imperative, particularly within the aviation sector, which is historically anchored in the consumption of fossil fuels.
Guo Tian, Chenxi Zhang, Fei Wei
doaj +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source