Results 31 to 40 of about 77,884 (269)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Nuclear Engineering and Technology, 2022 The earlier studies have analyzed theoretical links between nuclear energy and carbon dioxide (CO2) emissions concerning territorial (or production-based) emissions.
Danish, Recep Ulucak, Seyfettin Erdogan
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
, 2023 Climate change poses a severe threat to humanity for the last few decades. Various forms of natural disasters, extreme weather events, the outbreak of deadly diseases, life, and food insecurity are among common threats of climate change. The dissertation examines the relationships between political institutions and climate change.
openaire +2 more sources
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
CO2 emissions and soil carbon mineralisation under different systems
Agro@mbiente On-line, 2019 Usage and management alter the dynamics of soil organic carbon (SOC). The aim of this study was to compare the CO2 emissions in a Typic Humudept under different uses, and to relate the effects of CO2 emissions to the organic carbon content of the soil ...
André Carlos Auler +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Energies, 2017 China has become the world’s largest carbon dioxide (CO2) emitter. Sectoral production activities promote economic development while also adding considerably to national CO2 emissions.
Xin Yan, Jianping Ge
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
, 2021 This paper estimates an urban carbon dioxide emissions model using satellite-measured carbon dioxide concentrations from 2014 to 2020, for 1,236 cities in 138 countries. The model incorporates the global trend in carbon dioxide concentration, seasonal fluctuations by hemisphere, and a large set of georeferenced variables that incorporate carbon dioxide–
Dasgupta, Susmita +2 more
openaire +1 more source