Results 41 to 50 of about 77,884 (269)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Driving factors of CO2 emissions in South American countries: An application of Seemingly Unrelated Regression model

Regional Sustainability
Carbon emissions have become a critical concern in the global effort to combat climate change, with each country or region contributing differently based on its economic structures, energy sources, and industrial activities.
Gadir Bayramli, Turan Karimli
doaj   +1 more source

Role of economic growth, renewable energy, and technological innovation to achieve environmental sustainability in Kazakhstan

Current Research in Environmental Sustainability, 2022
Global climate change caused by Greenhouse gases (GHGs), particularly carbon dioxide (CO2) emissions, poses incomparable threats to the environment, development, and sustainability.
Asif Raihan, Almagul Tuspekova
doaj   +1 more source

CO2 emission and economic growth in Algeria [PDF]

Energy Policy, 2016
Ministerio de economía y competitividad (España) ECO 2014-56399-R.
Pablo-Romero Gil-Delgado, María del Populo, Bouznit, Mohammed   +1 more
openaire   +2 more sources

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Brazilian Productive Structure and Co2 Emissions [PDF]

SSRN Electronic Journal, 2010
This paper analyzes the relation between economic performance and CO2 emissions in Brazil, in the year 2004. The contribution of the productive sectors to total emission is established, taking into account the technological structure of the economy, the interrelations among sectors, the sectoral capacity of generating value-added and the participation ...
Imori, Denise, Guilhoto, Joaquim José Martins   +1 more
openaire   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

The externalities of solid fuel CO2 emissions on rice production: A time series analysis for Pakistan

Economic Journal of Emerging Markets, 2023
Purpose ― This study examines the externalities of CO2 emissions from solid fuel consumption on rice production in Pakistan using time series data from 1984 to 2021. Methods ― The independent variables include CO2 emissions from solid fuel consumption,
Mansoor Mushtaq, Arshad Mahmood Malik, Gulnaz Hameed   +2 more
doaj   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Forecasting interactive relationships and long-term equilibrium of CO2 emissions in industrial interdependent regions

Carbon Management, 2020
This is the first study that analyses the interactive relationships of carbon dioxide (CO2) emissions between China and Taiwan, two industrial dependent regions, by applying Lotka-Volterra equations.
Bi-Huei Tsai, Cheng-Chi Chen
doaj   +1 more source