Results 41 to 50 of about 1,345,233 (308)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Driving factors of CO2 emissions in South American countries: An application of Seemingly Unrelated Regression model

Regional Sustainability
Carbon emissions have become a critical concern in the global effort to combat climate change, with each country or region contributing differently based on its economic structures, energy sources, and industrial activities.
Gadir Bayramli, Turan Karimli
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

The Effects of Economic and Political Freedom on CO2 Emissions [PDF]

, 2003
In this paper we investigate the effects of political and economic freedom on CO2 emissions. As far as we know this is the first cross-country study of the relationship between economic freedom and environmental quality. Economic freedom is measured in
Lundström, Susanna, Carlsson, Fredrik
core   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

The externalities of solid fuel CO2 emissions on rice production: A time series analysis for Pakistan

Economic Journal of Emerging Markets, 2023
Purpose ― This study examines the externalities of CO2 emissions from solid fuel consumption on rice production in Pakistan using time series data from 1984 to 2021. Methods ― The independent variables include CO2 emissions from solid fuel consumption,
Mansoor Mushtaq, Arshad Mahmood Malik, Gulnaz Hameed   +2 more
doaj   +1 more source

Urban CO2 Emissions

, 2021
This paper estimates an urban carbon dioxide emissions model using satellite-measured carbon dioxide concentrations from 2014 to 2020, for 1,236 cities in 138 countries. The model incorporates the global trend in carbon dioxide concentration, seasonal fluctuations by hemisphere, and a large set of georeferenced variables that incorporate carbon dioxide–
Dasgupta, Susmita, Lall, Somik, Wheeler, David   +2 more
openaire   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Forecasting interactive relationships and long-term equilibrium of CO2 emissions in industrial interdependent regions

Carbon Management, 2020
This is the first study that analyses the interactive relationships of carbon dioxide (CO2) emissions between China and Taiwan, two industrial dependent regions, by applying Lotka-Volterra equations.
Bi-Huei Tsai, Cheng-Chi Chen
doaj   +1 more source