Results 41 to 50 of about 464,589 (306)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Laser-activated irrigation: Cavitation and streaming effects from dental lasers

Frontiers in Dental Medicine, 2023
IntroductionThe aim of the present study was to assess the generation of laser-activated irrigation (LAI) with a 9,300-nm CO2 laser, a 455- and 970-nm diode laser, as well as an 810- and 980-nm diode laser with and without carbon-coated “hot tips” for ...
Clara Isabel Anton y Otero, Laurine Marger, Enrico Di Bella, Enrico Di Bella, Albert Feilzer, Ivo Krejci   +5 more
doaj   +1 more source

A comparative study of the surface glaze characteristics of concrete treated with CO2 and high power diode lasers. Part II: mechanical, chemical and physical properties [PDF]

, 2000
The hardened ordinary Portland cement (OPC) surface layer of concrete which was glazed using a CO2 and a high power diode laser (see Part I of this paper) has been tested in order to determine the mechanical, chemical and physical characteristics of ...
Bungey, Carino, Dickson, Hall, J. Lawrence, L. Li, Lawrence, Petitbon, Petitbon, Vargin, Wilson   +10 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

High power coupled CO2 waveguide laser array [PDF]

, 1986
A hollow-bore ridge waveguide technique for phase locking arrays of coupled CO2 rf excited waveguide lasers was demonstrated. Stable phase-locked operation of two- and three-channel arrays has been demonstrated at the 50 W output level.
Bridges, W. B., Cantor, A. J., DeMaria, A. J., Hart, R. A., Kennedy, J. T., Newman, L. A.   +5 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Platelet-rich plasma versus combined fractional carbon dioxide laser with platelet-rich plasma in the treatment of vitiligo: a comparative study

Clinical, Cosmetic and Investigational Dermatology, 2018
Mostafa Kadry,1 Abeer Tawfik,2 Noha Abdallah,2 Ashraf Badawi,2,3 Hisham Shokeir2 1Faculty of Medicine, Dermatology Department, Helwan University Cairo, Helwan, Egypt; 2Dermatology Unit, Department of Medical Applications of Lasers (MAL), National ...
Kadry M, Tawfik A, Abdallah N, Badawi A, Shokeir H   +4 more
doaj  

Microneedling versus fractional CO2 laser in the treatment of atrophic postburn scars

Journal of the Egyptian Women’s Dermatologic Society, 2019
Background Microneedling is an evolving approach in the treatment of postburn scars based on the principle of collagen induction and neovascularization. Objective To evaluate and compare the clinical and histopathological outcome of microneedling versus
Amira A Zayed, Heba M Mashaly, Heba M Abdel Raheem, Eman El-Nabarawy, Marwa S El-Hawary, Olfat G Shaker, Reham S Elnemer, Waleed E Aldhahebi   +7 more
doaj   +1 more source

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source