Results 71 to 80 of about 412,356 (264)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Automatic Measurement of Alveolar CO2 in Small Animals

Experimental Biology and Medicine, 1949
SummaryAn infra-red CO2 analyzer having a measurement rate of seven analyses per second is described for continuous C02 tension determination over the expiration time (or volume). The value recorded from the last portion of expired air is regarded as “the alveolar C02 tension” if a plateau has developed during expiration.
K A, BLINN, W K, NOELL
openaire   +2 more sources

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Novel mainstream capnometer system is safe and feasible even under CO2 insufflation during ERCP-related procedure: a pilot study

BMJ Open Gastroenterology, 2019
Background and aimsThere is a need to safely achieve conscious sedation during endoscopic retrograde cholangiopancreatography (ERCP). We evaluated the safety and feasibility of a mainstream capnometer system to monitor apnoea during ERCP under CO2 ...
Haruhiko Ogata, Takanori Kanai, Yoichi Takimoto, Eisuke Iwasaki, Tatsuhiro Masaoka, Seiichiro Fukuhara, Shintaro Kawasaki, Takashi Seino, Tadashi Katayama, Kazuhiro Minami, Hiroki Tamagawa, Yujiro Machida   +11 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Real-time measurement and reaction rate analysis of CO2 absorption in cementitious materials by gas pressure monitoring using a batch reactor

Journal of CO2 Utilization
CO2-absorbing concrete is being actively researched toward carbon neutrality. Real-time measurement of CO2 absorption is essential to accurately assess the progress of the carbonation reaction, elucidate the carbonation mechanism through reaction rate ...
Katsuya Namiki, Vincentius Wilson, Misuzu Takase, Toshio Osawa, Suguru Noda   +4 more
doaj   +1 more source

An Assessment of Three Different In Situ Oxygen Sensors for Monitoring Silage Production and Storage

Sensors, 2016
Oxygen (O2) concentration inside the substrate is an important measurement for silage-research and-practical management. In the laboratory gas chromatography is commonly employed for O2 measurement. Among sensor-based techniques, accurate and reliable in
Guilin Shan, Yurui Sun, Menghua Li, Kerstin H. Jungbluth, Christian Maack, Wolfgang Buescher, Kai-Benjamin Schütt, Peter Boeker, Peter Schulze Lammers, Haiyang Zhou, Qiang Cheng, Daokun Ma   +11 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Mesure des flux de CO2 et bilan carboné de grandes cultures : état de la question et méthodologie [PDF]

Biotechnologie, Agronomie, Société et Environnement, 2008
CO2 flux measurement and carbon balance of agricultural crops. The increase of carbon dioxide (CO2) atmospheric concentration, which is a greenhouse gas, put in stress the need of a better understanding of the carbon cycle and its dynamic. In particular,
Bodson B., Moureaux C., Aubinet M.
doaj  

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source