Results 31 to 40 of about 644,330 (242)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Comparative Evaluation of Photovoltaic and Solar Thermal Installations for Water Heating at Hotel Casa Del Árbol Galerías in San Pedro Sula [PDF]

E3S Web of Conferences
This research arises from the growing need to reduce energy consumption and CO2 emissions in the hotel sector, which has traditionally relied on centralized heating systems based on fossil fuels. The primary objective of this study was to determine which
Davila J. Cruz, Parada María, Arriaga-Gutierrez A.   +2 more
doaj   +1 more source

Ultra-thin materials for electrocatalytic CO2 reduction to prepare liquid fuels

Cailiao gongcheng, 2022
The electrocatalytic CO2 reduction reaction (CO2RR) can not only alleviate the negative effects caused by excessive CO2, but also produce the carbon-containing fuels to alleviate energy shortages.
WANG Yuchao, LI Qian, ZENG Jian, TANG Shuaihao, ZHENG Huanran, XU Liang, CHEN Zhiyan, LEI Yongpeng   +7 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

New possibility for PET plastic recycling by a tailored hydrolytic enzyme

Green Energy & Environment
Plastic waste puts a huge burden on the ecosystem due to the current lack of mature recycling technology. Poly (ethylene terephthalate) (PET) is one of the most produced plastics in the world.
Shijie Yu, Qinghai Li, Yanguo Zhang, Hui Zhou   +3 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Phase-tuned performance of Ni-Ru supported molybdenum carbide catalysts for biomass and CO2 conversion

Materials Today Catalysis
With atmospheric CO2 levels persistently rising, CO2 management innovation is transitioning from strategic importance to operational urgency. This study investigates catalytic strategies for CO2 management through biomass CO2 gasification and reverse ...
Shiyu Zhang, Yuyao Yang, Yingbo Zhu, Xuan Bie, Qinghai Li, Yanguo Zhang, Hui Zhou   +6 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Unwrap Them First: Operando Potential- induced Activation Is Required when Using PVP-Capped Ag Nanocubes as Catalysts of CO2 Electroreduction

CHIMIA, 2021
Metallic nanoparticles of different shape can be used as efficient electrocatalysts for many technologically and environmentally relevant processes, like the electroreduction of CO2.
Maria de Jesus Galvez-Vazquez, Heng Xu, Pavel Moreno-Garcia, Yuhui Hou, Huifang Hu, Benjamin J. Wiley, Soma Vesztergom, Peter Broekmann   +7 more
doaj   +1 more source