Results 101 to 110 of about 154,360 (302)

Intracellular Aβ42 Sequestration by a Serine Protease Mitigates Neurotoxicity in a Drosophila Alzheimer's Disease Model

Advanced Science, EarlyView.
Emerging evidence suggests that intraneuronal Aβ accumulation represents an early pathogenic event in Alzheimer's disease (AD). Using Drosophila AD model, this study shows that a nonsecreted serine protease Yip7 physically interacts with Aβ. This causes intraneuronal Aβ accumulation but surprisingly reduces the associated neurotoxicity, arguing that ...
Jingyun Su, Meng Yang, Xinfeng Wang, Pa Wu, Zongzhao Zhai   +4 more
wiley   +1 more source

CO2-water displacement characteristics of saturated sandstones with different pore structures

Meitian dizhi yu kantan
ObjectiveThe pore structures of clastics play a crucial role in assessing the potential of saline aquifers for geologic CO2 sequestration. Current studies on pore structures during CO2 sequestration focus primarily on artificial cores.
Ting LIU, Jinglin LI, Yi LI, Wendong DAN, Yujie DIAO, Xin MA   +5 more
doaj   +1 more source

Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis

Advanced Science, EarlyView.
Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason, Anindya Sen, Suhan Cho, Se Jong Lee, Keyata Thompson, Md Musavvir Mahmud, Poornima Dubey, Talia Guardia, Anthony Kim, Stuart Martin, Nathan Wright, Konstantinos Konstantopoulos, Aikaterini Kontrogianni‐Konstantopoulos   +12 more
wiley   +1 more source

Effect of sodium dodecyl sulphate on the rheological and carbon sequestration properties of cemented paste backfill with CO2 injection

Frontiers in Earth Science
Cemented paste backfill (CPB) is a technology that has a positive impact on both the environment and mining safety. In recent years, it has been widely applied and developed.
Zhuo Shen, Yibo Zhou
doaj   +1 more source

Soil carbon sequestration rates under Mediterranean woody crops using recommended management practices : A meta-analysis [PDF]

, 2016
This work was supported by the projects: CARBOLIVAR (P11-RNM-7186) funded by Consejería de Innovación, Ciencia y Empresa of Junta de Andalucía and GEISpain project (CGL2014‐52838‐C2‐1‐R) funded by Ministerio de Economía y Competitividad, both including ...
Aguilera, Eduardo, Francaviglia, Rosa, Garcia-Ruiz, Roberto, Smith, Pete, Vicente-Vicente, José Luis   +4 more
core   +1 more source

Tetrastigma Hemsleyanum Polysaccharide Suppresses Triple‐Negative Breast Cancer by Disrupting the Hippo‐YAP/TEAD4‐PDIA4 Axis and Endoplasmic Reticulum Stress Adaptation

Advanced Science, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) exhibits addiction to chronic endoplasmic reticulum (ER) stress, which sustains an aggressive metastatic phenotype through activation of the unfolded protein response (UPR). Here, we identify a previously unrecognized “ER‐stress addiction” axis in which the Hippo pathway effector TEAD4 directly ...
Yini Shang, Wentao Si, Youxue Zhang, Jialin Liu, Huaixi Zhang, Yafei Li, Hongmeng Su, Wei Jiang, Zhishan Ding, Lihong Wang   +9 more
wiley   +1 more source

Low Greenhouse Gas Agriculture: Mitigation and Adaptation Potential of Sustainable Farming Systems [PDF]

, 2009
Is low greenhouse gas emission (GHG) agriculture possible? Is it, in fact, desirable? In seeking answers to these two basic but extremely relevant questions, this study examines current farming practices, and incorporates scientific databases from ...
Fließbach, A., Hepperly, P., Niggli, U., Scialabba, N.   +3 more
core  

DOTA‐grafted Cationic Polymers Behaving as Powerful Macromolecular Resistance‐reversal Agents (MRRAs) Combating Against New Delhi Metallo‐β‐lactamase (NDM)‐producing Bacteria

Advanced Science, EarlyView.
Two macromolecular resistance‐reversal agents (MRRAs)—linear (MRRAL) and nanostructured (MRRAN) polymers were fabricated by integrating DOTA motifs into tunable polycationic scaffolds. MRRAs exhibit superior antibacterial potency once combined with meropenem (MEM) through (i) bacterial membrane disruption via localized cationic charge and ...
Ruixue Wang, Jian Zhang, Yun li, Liping Qiao, Zhuorui Dong, Dandan Cui, Peirong Bai, Liping Li, Bing Cao, Ruiping Zhang   +9 more
wiley   +1 more source

Biochar-amended soil can further sorb atmospheric CO2 for more carbon sequestration

Communications Earth & Environment
Input of biochar into soil is considered as an efficient technology for carbon sequestration. This work is aimed to explore if the extra sorption of carbon dioxide (CO2) exists in the biochar-amended soil, which has not yet received attention.
Xiangyang Gui, Xiaoyun Xu, Zehong Zhang, Liyang Hu, Wenfeng Huang, Ling Zhao, Xinde Cao   +6 more
doaj   +1 more source

Performance analysis of thermal energy storage for space heating and CO2 sequestration in depleted oil and gas reservoirs

地质科技通报
Objective Thermal energy storage and CO2 sequestration in depleted oil and gas reservoirs can not only solve the problem of seasonal solar thermal energy storage but also increase the share of renewable energy space heating and enhance the economy of CO2
Yanxin WANG
doaj   +1 more source