Results 51 to 60 of about 175,533 (262)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Migration characteristics and storage forms of liquid and supercritical CO2 in saline aquifers

Meitian dizhi yu kantan
ObjectiveCO2 storage in saline aquifers serves as a critical technology used to dramatically reduce greenhouse gas emissions. Owing to the low-temperature marine environment and the pressure from overlying seawater, shallow offshore saline aquifers ...
Xiyi PENG, Yanyong WANG, Song LI, Xiaoguang WANG, Guodong CUI, Yongming HE   +5 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Establishment of evaluation indexes and target formation selection for CO2 storage stability in saline aquifer

Shenzhen Daxue xuebao. Ligong ban
CO2 storage in saline aquifers is considered to be pathway major approach to mitigating the greenhouse effect. However, the long-term CO2 storage stability is affected by reservoir characteristics and injection parameters, and there is currently a lack ...
CUI Chuanzhi, LI Anhui, LI Jinghong, WANG Junkang, MA Siyuan   +4 more
doaj   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

CO2 Geological Storage Using the Clathrate Hydrate

Journal of MMIJ
Carbon dioxide capture and storage (CCS) is expected to be a key decarbonization technology for achieving carbon neutrality. Sensitivity analyses using an energy system model on CCS costs and storage capacity indicate that increasing domestic CO2 storage
Takaomi TOBASE, Takashi OTSUKI, Toru SATO, Asuka ICHIE, Yosuke SAWANO   +4 more
doaj   +1 more source

Application of the PROMETHEE and VIKOR methods for selecting the most suitable carbon dioxide geological storage option [PDF]

Podzemni Radovi, 2019
CO2 storage in geological formations is one of the leading solutions for mitigation of greenhouse gas emissions. Types of geological formations that can be used for CO2 storage, that are discussed in this paper are: depleted oil and gas reservoirs ...
Tomić Lola, Karović-Maričić Vesna, Danilović Dušan, Leković Branko, Crnogorac Miroslav   +4 more
doaj  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Numerical simulations of the safety of geologic CO2 storage in saline aquifers in the Enping Sag, Pearl River Mouth Basin

Meitian dizhi yu kantan
Background Since the beginning of the Industrial Revolution, excessive CO2 emissions have aggravated the greenhouse effect. Against this backdrop, CO2 capture, utilization, and storage (CCUS) technology has emerged as a critical countermeasure ...
Tao YU, Xiwen LI, Yunshi YANG, Bingbing CHEN, Zemin JI, Chang HE, Lanlan JIANG, Yongchen SONG   +7 more
doaj   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source