Results 241 to 250 of about 11,106 (283)

Fertility and Early Embryonic Development Toxicity of hzVSF‐v13 in Sprague–Dawley Rats

open access: yesJournal of Applied Toxicology, Volume 46, Issue 2, Page 560-568, February 2026.
ABSTRACT Humanized virus suppressing factor–variant 13 (hzVSF‐v13), a monoclonal IgG4 antibody, is a potential therapeutic candidate for COVID‐19. Although fertility and embryonic developmental toxicity studies are crucial for the safety evaluation of new drugs, the toxicological profile of hzVSF‐v13 remains unexplored.
Ji‐Seong Jeong   +10 more
wiley   +1 more source

Acute Toxicity and Genotoxicity of cMoL, a Lectin From Moringa oleifera Seeds With Antifungal Activity Against Cryptococcus Strains

open access: yesJournal of Applied Toxicology, Volume 46, Issue 2, Page 682-696, February 2026.
ABSTRACT Coagulant Moringa oleifera lectin (cMoL) is one of the compounds involved in the application of M. oleifera seeds for traditional water treatment methods. The present study highlights the new biotechnological potential of cMoL lectin as an antifungal agent against Cryptococcus neoformans B3501 and H99 and Cryptococcus gattii R265 strains ...
Matheus Cavalcanti de Barros   +16 more
wiley   +1 more source

Matrix Type Influences the Levels of Soluble Immune Checkpoints

open access: yesJournal of Clinical Laboratory Analysis, Volume 40, Issue 3, February 2026.
This study aimed to assess whether the quantification of soluble immune checkpoints (sICs) is comparable between serum and EDTA‐plasma samples. We quantified 17 sICs by a multiplex bead‐based assay in paired serum and plasma‐EDTA samples collected from a cohort of 38 healthy subjects.
Veronica Buia   +7 more
wiley   +1 more source

Circulating Metabolites Treat Human TMJ‐OA by Eliminating Senescent Chondrocytes via the C1QBP/C1q/p14ARF Axis

open access: yesJournal of Extracellular Vesicles, Volume 15, Issue 2, February 2026.
ABSTRACT Temporomandibular joint osteoarthritis (TMJ‐OA) is a progressive degenerative disorder, for which therapeutic interventions remain limited. The disruption of metabolic homeostasis plays a critical role in the pathogenesis and advancement of TMJ‐OA.
Bowen Meng   +19 more
wiley   +1 more source

Comparison of Endoscopic Therapies for Small Rectal Neuroendocrine Tumors: Endoscopic Muscularis Superficialis Dissection Versus Endoscopic Submucosal Dissection

open access: yesJGH Open, Volume 10, Issue 2, February 2026.
ABSTRACT Background and Aim Rectal neuroendocrine tumors (rNETs) often exhibit submucosal tumor‐like growth. While endoscopic submucosal dissection (ESD) is widely used, it carries a risk of positive vertical margins, often necessitating repeated surveillance and imposing both financial and psychological burdens on patients. To address this limitation,
Xiawen Shu   +9 more
wiley   +1 more source

Automated laser retraction for targeted glioblastoma coverage during laser interstitial thermal therapy

open access: yesMedical Physics, Volume 53, Issue 2, February 2026.
Abstract Background Current magnetic resonance guided laser interstitial thermal therapy (MRgLITT) requires physician input to incrementally retract the laser probe during glioblastoma (GBM) treatment, to achieve maximum safe lesion coverage (LC). Objective Through this computational study, we propose an automated MRgLITT system based on temperature ...
Shreeniket Pawar   +7 more
wiley   +1 more source

Determining Preclinical Safety of Aclarubicin in Pediatric Malignancies

open access: yesPediatric Blood &Cancer, Volume 73, Issue 2, February 2026.
ABSTRACT Background Anthracyclines are among the most effective chemotherapeutic agents used to treat pediatric malignancies. However, their clinical use is limited by dose‐dependent toxicities, particularly cardiotoxicity and secondary malignancies.
Darleen S. Tu   +15 more
wiley   +1 more source

Resveratrol attenuates areca nut extract‐induced chronic colitis by suppressing pyroptosis of intestinal epithelial cells via modulating cGAS/STING signaling

open access: yesVIEW, Volume 7, Issue 1, February 2026.
Areca nut extract (ANE), commonly consumed in some cultures, can damage gut cells by triggering inflammation and cell death through a pathway called cGAS‐STING. This leads to the release of harmful inflammatory substances and weakens the gut barrier. Our study shows that resveratrol, a natural compound found in foods like grapes, can block this harmful
Jing Zhang   +4 more
wiley   +1 more source

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