Results 251 to 260 of about 117,766 (329)

Coronary Ectasia and ST Elevation Myocardial Infarction Patients: Does Atherosclerosis Influence Periprocedural Management and Long‐Term Prognosis?

open access: yesCatheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Coronary artery ectasia (CAE) influences procedural outcomes in the context of ST‐elevation myocardial infarction (STEMI); however, its relationship with atherosclerotic coronary artery disease (ACAD) remains unclear. Aims This study aimed to compare clinical and procedural characteristics, as well as outcomes, in patients with ...
Victorine Fraichot   +6 more
wiley   +1 more source

Prevalence of iron deficiency in patients with mild to moderate bleeding disorders and bleeding disorder of unknown cause. [PDF]

open access: yesRes Pract Thromb Haemost
Dreier T   +8 more
europepmc   +1 more source

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Multiple Ascending Doses and Dose Titration of Bexicaserin in Healthy Participants in a Randomized, Double‐Blind, Placebo‐Controlled Study

open access: yesClinical Pharmacology in Drug Development, EarlyView.
Abstract Bexicaserin (LP352) is a selective superagonist of the 5‐hydroxytryptamine 2C (5‐HT2C) receptor currently in development for the treatment of seizures that arise from developmental and epileptic encephalopathies. This phase 1, double‐blind, placebo‐controlled multiple ascending dose (MAD) study assessed the safety, tolerability, and ...
Jonathan Williams   +7 more
wiley   +1 more source

Evolving Real‐World Data and Evidence Use for New Drugs and Regenerative Medical Products Approvals in Japan—An Analysis of the 6‐Year Trend

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Several regulatory initiatives have been made to clarify the acceptability and requirements of real‐world data and real‐world evidence (RWD/E) for the benefit/risk assessment of new medical products in Japan. The objectives of this review were to characterize the use of RWD/E in regulatory applications of new medical products and to describe the ...
Suguru Okami   +2 more
wiley   +1 more source

The Cenomanian–Turonian boundary interval in the Western Canada Foreland Basin: Stratigraphy, geochemistry, geochronology and sea‐level changes recorded in expanded and condensed clastic successions

open access: yesThe Depositional Record, EarlyView.
Shallow‐marine mudstone of the Cretaceous Kaskapau Formation in the British Columbia foredeep preserves a 185 m thick record of OAE2. The organic carbon‐isotope and osmium‐isotope excursions can be correlated in detail with other Cenomanian–Turonian boundary sections around the world.
A. Guy Plint   +12 more
wiley   +1 more source

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