Results 51 to 60 of about 13,985,312 (367)

Determination of sample stability for a broad panel of coagulation parameters and factor assays on the Cobas t 711 analyzer starting from fresh-never-frozen plasma

Frontiers in Molecular Biosciences
BackgroundPreanalytical procedures can affect the accuracy of coagulation assay results. Recommended plasma storage temperatures and durations need to be defined for individual coagulation assays.
Michael Hoffmann, Norbert Gottschalk, Philipp Huber, Vanessa Scheling, Nicole von Allmen, J. Kolja Hegel   +5 more
doaj   +1 more source

Factor XI deficiency case reports on congenital and acquired Hemophilia C - A case report

Apollo Medicine, 2022
Introduction: Factor XI deficiency or hemophilia C is a very rare coagulation factor deficiency, with a global incidence of 1 in 1 million. Although it is an under-recognized entity, it can cause significant bleeding, resulting in life-threatening ...
Mamta Soni, Srikanth Muralikrishnan, Supraja Sundaram   +2 more
doaj   +1 more source

Advancement in liver laparoscopic resection – development of a new surgical device

Brazilian Journal of Medical and Biological Research, 2018
Liver resection is the standard treatment for any liver lesion. Laparoscopic liver resection is associated with lower intra-operative blood loss and fewer complications than open resection.
P. Vavra, L. Karnik, M. Skrobankova, J. Jurcikova, P. Ihnat, P. Zonca, M. Peteja, A. El-Gendi, S. Czudek   +8 more
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Breakfast can Affect Routine Hematology and Coagulation Laboratory Testing: An Evaluation on Behalf of COLABIOCLI WG-PRE-LATAM

TH Open, 2019
Laboratories worldwide perform both hematological and coagulation testing on patients avoiding fasting time. In 2017, the Latin America Confederation of Clinical Biochemistry (COLABIOCLI) commissioned the Latin American Working Group for Preanalytical ...
Maria Elena Arredondo, Eduardo Aranda, Rubén Astorga, Lorena Michele Brennan-Bourdon, Marise Danielle Campelo, Silvia Flores, Claudio Medel, Ignacio Manríquez, Patricia Ochoa, Beatriz Varela, Carlos Vega Salinas, Gabriel Lima-Oliveira   +11 more
doaj   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

Lupus Antibody Mimicking Reduced Plasmatic Coagulation in a Patient With Atrial Fibrillation and Ischemic Stroke

Frontiers in Neurology, 2020
Background: Lupus anticoagulant (LA) owns procoagulant properties in vivo and prolongs phospholipid-dependent clotting times in vitro. The prolonged in vitro clotting time can be misinterpreted as a bleeding disorder.
Aydin Huseynov, Aydin Huseynov, Verena Haselmann, Maximillian Kittel, Thomas Bertsch, Angelika Alonso, Michael Neumaier, Martin Borggrefe, Martin Borggrefe, Ursula Hoffmann, Ursula Hoffmann   +10 more
doaj   +1 more source

Update on laboratory testing and hemostasis assessment in patients receiving direct oral anticoagulants (DOACs)

Thrombosis Update, 2021
Direct oral anticoagulants (DOACs) have been established and already registered worldwide for clinical use. Contrary to vitamin K antagonists, their mode of action is based on the direct inhibition of the single coagulation enzymes factor Xa or IIa. Even
Vasilios Perifanis, Nikolaos Neokleous, Dimitrios A. Tsakiris   +2 more
doaj   +1 more source

Intraoperative changes in blood coagulation and thrombelastographic monitoring in liver transplantation [PDF]

, 1985
The blood coagulation system of 66 consecutive patients undergoing consecutive liver transplantations was monitored by thrombelastograph and analytic coagulation profile.
Bontempo, FA, Kang, YG, Lewis, JH, Marquez, J, Martin, DJ, Shaw, BW, Starzl, TE, Winter, PM   +7 more
core   +1 more source