Results 171 to 180 of about 5,615 (251)

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

"Making our voices count": patient action groups as a strategy to engage people with lived experience in implementation of an intervention for hypertensive disorders of pregnancy. [PDF]

Front Health Serv
Hodges J, Fatima H, McHugh K, Medearis Costello J, Barnett K, Farahi N, Greene-Jones J, Jones D, Ledford A, Lewis LD, Lopez J, Smith-Janey S, Quezada M, Menard MK, Lightfoot AF.   +14 more
europepmc   +1 more source

Artificial Intelligence and Mental Well‐Being in Adult Education: Implications for Practice and Professional Responsibility

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Mental well‐being is central to adult learner success, yet many adult education institutions lack capacity to provide timely and accessible support. This article examines how artificial intelligence (AI) can strengthen mental health–adjacent supports in adult and continuing higher education, with attention to professional practice and ...
Adam L. McClain, Thomas Wade
wiley   +1 more source

Safety and Immunogenicity of a Severe Acute Respiratory Syndrome Coronavirus 2 Spike Subunit Vaccine Stabilized in the Prefusion Conformation by a Second-Generation Molecular Clamp and Evaluated in Adults Aged 18-55 Years: A Randomized, Double-Blind, Active Comparator, Phase I Trial. [PDF]

J Infect Dis
Chappell KJ, Mordant FL, Amarilla AA, Modhiran N, Liang B, Li Z, Lackenby JA, Jaberolansar N, O'Donnell J, Kienzle V, Kommajosyula V, Tardiota N, Bennet JK, Henderson CL, Dalrymple RL, Goh J, Hoger K, Gillard M, Jones ML, Hughes K, Hughes B, Barnes J, Reading PC, Ranasinghe C, Subbarao K, Munro TP, Young PR, Watterson D.   +27 more
europepmc   +1 more source

A Generalization of the Social Coalitional Equilibrium Structure

A Generalization of the Social Coalitional Equilibrium Structure
論文 We generalize the notion of Ichiishi (1981)’s social coalitional equilibrium to the multiple coalition structures, so that different industries having independent coalition-deviation opportunities and their industrial organizations are simultaneously determined.
openaire  

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Separating the generational effects of temperature and viscosity on the body size of a freshwater Mesocyclops copepod. [PDF]

Biol Open
Wagner Z, Wagner G, Fields DM, Yen J.
europepmc   +1 more source

Brainstem and Cerebellar Volume Loss and Associated Clinical Features in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Progressive Supranuclear Palsy (PSP) is a neurodegenerative ‘tauopathy’ with predominating pathology in the basal ganglia and midbrain. Caudal tau spread frequently implicates the cerebellum; however, the pattern of atrophy remains equivocal.
Chloe Spiegel, Timothy P. Siejka, Cassandra Marotta, Josh J. Y. Lee, Kelly Bertram, Terence J. O'Brien, Meng Law, Lucy Vivash, Ian H. Harding   +8 more
wiley   +1 more source

Why Should a Genome Be Protected? Ethical, Legal, and Security Challenges in the Protection of Genomic Data. [PDF]

Biology (Basel)
Szalata M, Danielewski M, Wielgus K, Słomski R.   +3 more
europepmc   +1 more source

Impact of Asymptomatic Intracranial Hemorrhage on Outcome After Endovascular Stroke Treatment

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Endovascular treatment (EVT) achieves high rates of recanalization in acute large‐vessel occlusion (LVO) stroke, but functional recovery remains heterogeneous. While symptomatic intracranial hemorrhage (sICH) has been well studied, the prognostic impact of asymptomatic intracranial hemorrhage (aICH) after EVT is less certain ...
Shihai Yang, Chengsong Yue, Zhuang Li, Xiaolei Shi, Haoxuan Zhu, Jie Yang, Linyu Li, Jiaxing Song, Shitao Fan, Gaoming Li, Wenzhe Sun, Zhixian Ye, Jiacheng Huang, Dahong Yang, Jinfu Ma, Xu Xu, Zhixi Wang, Lilan Wang, Guojian Liu, Fengli Li, Changwei Guo, Li Qi, Wenjie Zi   +22 more
wiley   +1 more source