Results 221 to 230 of about 214,929 (306)

Application of patient-specific surgical guides in foot and ankle surgery. [PDF]

Acta Orthop Traumatol Turc
Kavak S, Ozturk B, Ogut T, DiGiovanni CW, Ashkani-Esfahani S, Karaismailoglu B.   +5 more
europepmc   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Governance and policy in global neurosurgery: a scoping review of national and international efforts. [PDF]

Neurosurg Rev
Dos Santos Rubio E, Brice KS, Toussaint F, Colado-Martinez J, Thrash GW, Ahmed AA, Kelbert J, Johnson W.   +7 more
europepmc   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Development and implementation of food and nutrition labelling policies in Mongolia: a policy analysis. [PDF]

Public Health Nutr
Chimedtseren N, Kelly B, Yeatman H, McMahon AT, Jamiyan B.   +4 more
europepmc   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Artificial Intelligence and Stigma in Addiction Research: Insights From the HEALing Communities Study Coalition Meetings. [PDF]

J Addict Med
El-Bassel N, David JL, Aragundi E, Walters ST, Wu E, Gilbert L, Chandler R, Hunt T, Frye V, Campbell ANC, Goddard-Erich DA, Chen M, Davé P, Benjamin SN, Lounsbury D, Sabounchi N, Aggarwal M, Feaster D, Huang T, Zheng T.   +19 more
europepmc   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Enhancing Thrombolysis Times in Acute Ischemic Stroke With Regional Dashboards: Results From the Florida Stroke Registry. [PDF]

J Am Heart Assoc
Del Brutto VJ, Gutierrez CM, Ying H, Gardener H, Veledar E, Jameson A, Scheppke KA, Rose DZ, Sand C, Antevy P, Hylton T, Gordon Perue G, Asdaghi N, Rundek T, Mehta BP, Romano JG.   +15 more
europepmc   +1 more source