Results 91 to 100 of about 6,491,357 (404)

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Revealing the genetic basis of coat color in Tibetan sheep through selective sweep and transcriptomic analyses

Frontiers in Veterinary Science
Background and objectiveCoat color is an important economic trait in animal husbandry and plays a crucial role in the adaptability of animal. As a key economic trait in high-altitude areas, the genetic mechanisms regulating coat color in Tibetan sheep ...
Xue Li, Buying Han, Dehong Tian, Dehui Liu, Dehui Liu, Wulong Ma, Guangcai Bao, Lei Wang, Quanbang Pei, Zian Zhang, Kai Zhao   +10 more
doaj   +1 more source

Multiple structural alignment for distantly related all b structures using TOPS pattern discovery and simulated annealing [PDF]

, 2003
Topsalign is a method that will structurally align diverse protein structures, for example, structural alignment of protein superfolds. All proteins within a superfold share the same fold but often have very low sequence identity and different biological
Gilbert, D, Westhead, DR, Williams, A
core   +1 more source

Translational Repression and Specific RNA Binding by the Coat Protein of the Pseudomonas Phage PP7*

Journal of Biological Chemistry, 2001
PP7 is a single-strand RNA bacteriophage of Pseudomonas aeroginosa and a distant relative to coliphages like MS2 and Qβ. Here we show that PP7 coat protein is a specific RNA-binding protein, capable of repressing the translation of sequences fused to the
F. Lim, Thomas P. Downey, D. Peabody
semanticscholar   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

The structure of the COPII transport-vesicle coat assembled on membranes

eLife, 2013
Coat protein complex II (COPII) mediates formation of the membrane vesicles that export newly synthesised proteins from the endoplasmic reticulum. The inner COPII proteins bind to cargo and membrane, linking them to the outer COPII components that form a
Giulia Zanetti, Simone Prinz, Sebastian Daum, Annette Meister, Randy Schekman, Kirsten Bacia, John AG Briggs   +6 more
doaj   +1 more source

Antimicrobial peptides: agents of border protection for companion animals. [PDF]

, 2012
Over the past 20 years, there have been significant inroads into understanding the roles of antimicrobial peptides in homeostatic functions and their involvement in disease pathogenesis.
Affolter, Verena K, Bevins, Charles L, Leonard, Brian C   +2 more
core   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Yeast Irc6p is a novel type of conserved clathrin coat accessory factor related to small G proteins. [PDF]

, 2012
Clathrin coat accessory proteins play key roles in transport mediated by clathrin-coated vesicles. Yeast Irc6p and the related mammalian p34 are putative clathrin accessory proteins that interact with clathrin adaptor complexes.
Cascio, Duilio, Costaguta, Giancarlo, Daboussi, Lydia, Gorynia, Sabine, Lorenz, Todd C, Payne, Gregory S   +5 more
core   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source