Results 121 to 130 of about 6,491,357 (404)

The Coat Protein of Citrus Yellow Vein Clearing Virus Interacts with Viral Movement Proteins and Serves as an RNA Silencing Suppressor

open access: yesViruses, 2019
Citrus yellow vein clearing virus is a newly accepted member of the genus Mandarivirus in the family Alphaflexiviridae. The triple gene block proteins (TGBp1, TGBp2 and TGBp3) encoded by plant viruses in this family function on facilitating virus ...
Atta Ur Rehman   +7 more
doaj   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

open access: yesMolecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster   +3 more
wiley   +1 more source

Dynamics of green fluorescent protein mutant2 in solution, on spin‐coated glasses, and encapsulated in wet silica gels [PDF]

open access: bronze, 2002
Giuseppe Chirico   +7 more
openalex   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

open access: yesMolecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici   +8 more
wiley   +1 more source

Identification of a zucchini yellow mosaic virus infecting squash in Hangzhou

open access: yes浙江大学学报. 农业与生命科学版, 2003
A filamentous virus was isolated from naturally infected squash (Cucuribita moschata L.), showing yellow mosaic in Hangzhou, Zhejiang Province, in autumn 1999. This virus was found to cause systemic symptoms on all the Cucuribitaceae plants tested.
CHEN Jie-yun   +3 more
doaj   +1 more source

Protein–lipid interactions of bacteriophage M13 major coat protein

open access: yesBiochimica et Biophysica Acta (BBA) - Biomembranes, 2003
During the past years, remarkable progress has been made in our understanding of the replication cycle of bacteriophage M13 and the molecular details that enable phage proteins to navigate in the complex environment of the host cell. With new developments in molecular membrane biology in combination with spectroscopic techniques, we are now in a ...
Stopar, D.   +3 more
openaire   +2 more sources

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

open access: yesMolecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert   +13 more
wiley   +1 more source

Biochemical, histochemical and ultrastructural characterization of Centrolobium robustum (Fabaceae) seeds

open access: yesHoehnea
Centrolobium robustum seed coat is made up of an external layer of macrosclereids and an internal layer of osteosclereids, followed by a layer of dead cells.
Javier Alberto Pinzón-Torres   +3 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

open access: yesMolecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak   +8 more
wiley   +1 more source

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