Results 181 to 190 of about 6,491,357 (404)

Assembly of COPI and COPII Vesicular Coat Proteins on Membranes.

open access: yesAnnual Review of Biophysics, 2018
J. Béthune, F. Wieland
semanticscholar   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Membrane insertion mechanism of the caveola coat protein Cavin1. [PDF]

open access: yesProc Natl Acad Sci U S A, 2022
Liu KC   +12 more
europepmc   +1 more source

Genomic classification of fish nodaviruses by molecular phylogenetic analysis of the coat protein gene

open access: yesApplied and Environmental Microbiology, 1997
T. Nishizawa   +4 more
semanticscholar   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Phylodynamics and Coat Protein Analysis of Babaco Mosaic Virus in Ecuador. [PDF]

open access: yesPlants (Basel), 2022
Mosquera-Yuqui F   +10 more
europepmc   +1 more source

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