Results 51 to 60 of about 7,236,618 (362)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

P1 of strawberry vein banding virus, a multilocalized protein, functions as a movement protein and interacts with the coat protein

Journal of Integrative Agriculture, 2022
Although the complete nucleotide sequence of strawberry vein banding virus (SVBV) has been determined and bioinformatic analysis has revealed that the SVBV genome could encode seven proteins, the precise function of each protein is unclear.
Peng-huan RUI, Zhan-qi WANG, Wen-shu SHAN, Wei-wei XIA, Xiu-hong ZHOU, Lian-lian YANG, Lei JIANG, Tong JIANG   +7 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Production of polyclonal antiserum against beet western yellows virus coat protein expressed in Escherichia coli

Journal of Crop Protection, 2015
Serological methods are commonly used methods for detection of viruses. Preparation of pure viral antigens is a crucial step in production of antibodies required for serological studies.
Arezu Lotfi, Masoud Shams-Bakhsh, Bagher Yakhchali   +2 more
doaj  

Distribution of Wheat-Infecting Viruses and Genetic Variability of Wheat Streak Mosaic Virus and Barley Stripe Mosaic Virus in Kazakhstan

Viruses
Wheat is an essential cereal crop for the economy and food safety of Kazakhstan. In the present work, a screening of wheat and barley from different regions of Kazakhstan was conducted using newly developed specific primers for reverse transcription PCR ...
Anastasiya Kapytina, Mariya Kolchenko, Nazym Kerimbek, Alexandr S. Pozharskiy, Gulnaz Nizamdinova, Aisha Taskuzhina, Kamila Adilbayeva, Marina Khusnitdinova, Malika Amidullayeva, Ruslan Moisseyev, Zulfiya Kachiyeva, Dilyara Gritsenko   +11 more
doaj   +1 more source

Egg Coat Proteins Across Metazoan Evolution [PDF]

, 2018
All animal oocytes are surrounded by a glycoproteinaceous egg coat, a specialized extracellular matrix that serves both structural and species-specific roles during fertilization. Egg coat glycoproteins polymerize into the extracellular matrix of the egg coat using a conserved protein-protein interaction module-the zona pellucida (ZP) domain-common to ...
Emily E, Killingbeck, Willie J, Swanson
openaire   +2 more sources

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

MS2 virus-like particles as a versatile platform for multi-disease vaccines: a review

Frontiers in Immunology
The coat protein of the MS2 self-assembles into virus-like particles (VLPs) with a diameter of 26 nm. These VLPs are devoid of the phage genome yet are efficiently recognized by the immune system, eliciting robust humoral and cellular immune responses ...
Guodong Zhou, Guodong Zhou, Zhili Luo, Zhihui Zhang, Zhihui Zhang, Shengliang Cao, Shengliang Cao, Yubao Li, Yubao Li, Yubao Li   +9 more
doaj   +1 more source

Coatopathies: Genetic Disorders of Protein Coats

Annual Review of Cell and Developmental Biology, 2019
Protein coats are supramolecular complexes that assemble on the cytosolic face of membranes to promote cargo sorting and transport carrier formation in the endomembrane system of eukaryotic cells. Several types of protein coats have been described, including COPI, COPII, AP-1, AP-2, AP-3, AP-4, AP-5, and retromer, which operate at different stages of ...
Esteban C, Dell'Angelica, Juan S, Bonifacino   +1 more
openaire   +3 more sources