Results 81 to 90 of about 6,491,357 (404)

Egg Coat Proteins Across Metazoan Evolution [PDF]

, 2018
All animal oocytes are surrounded by a glycoproteinaceous egg coat, a specialized extracellular matrix that serves both structural and species-specific roles during fertilization. Egg coat glycoproteins polymerize into the extracellular matrix of the egg coat using a conserved protein-protein interaction module-the zona pellucida (ZP) domain-common to ...
Emily E, Killingbeck, Willie J, Swanson
openaire   +2 more sources

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

Distribution of Wheat-Infecting Viruses and Genetic Variability of Wheat Streak Mosaic Virus and Barley Stripe Mosaic Virus in Kazakhstan

Viruses
Wheat is an essential cereal crop for the economy and food safety of Kazakhstan. In the present work, a screening of wheat and barley from different regions of Kazakhstan was conducted using newly developed specific primers for reverse transcription PCR ...
Anastasiya Kapytina, Mariya Kolchenko, Nazym Kerimbek, Alexandr S. Pozharskiy, Gulnaz Nizamdinova, Aisha Taskuzhina, Kamila Adilbayeva, Marina Khusnitdinova, Malika Amidullayeva, Ruslan Moisseyev, Zulfiya Kachiyeva, Dilyara Gritsenko   +11 more
doaj   +1 more source

Coatopathies: Genetic Disorders of Protein Coats

Annual Review of Cell and Developmental Biology, 2019
Protein coats are supramolecular complexes that assemble on the cytosolic face of membranes to promote cargo sorting and transport carrier formation in the endomembrane system of eukaryotic cells. Several types of protein coats have been described, including COPI, COPII, AP-1, AP-2, AP-3, AP-4, AP-5, and retromer, which operate at different stages of ...
Esteban C, Dell'Angelica, Juan S, Bonifacino   +1 more
openaire   +3 more sources

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

MS2 virus-like particles as a versatile platform for multi-disease vaccines: a review

Frontiers in Immunology
The coat protein of the MS2 self-assembles into virus-like particles (VLPs) with a diameter of 26 nm. These VLPs are devoid of the phage genome yet are efficiently recognized by the immune system, eliciting robust humoral and cellular immune responses ...
Guodong Zhou, Guodong Zhou, Zhili Luo, Zhihui Zhang, Zhihui Zhang, Shengliang Cao, Shengliang Cao, Yubao Li, Yubao Li, Yubao Li   +9 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Incidence and Molecular Identification of Apple Necrotic Mosaic Virus (ApNMV) in Southwest China

Plants, 2020
Apple mosaic disease has a great influence on apple production. In this study, an investigation into the incidence of apple mosaic disease in southwest China was performed, and the pathogen associated with the disease was detected.
Wensen Shi, Rundong Yao, Runze Sunwu, Kui Huang, Zhibin Liu, Xufeng Li, Yi Yang, Jianmei Wang   +7 more
doaj   +1 more source

The developmental cell biology of Trypanosoma brucei [PDF]

, 2005
Trypanosoma brucei provides an excellent system for studies of many aspects of cell biology, including cell structure and morphology, organelle positioning, cell division and protein trafficking. However, the trypanosome has a complex life cycle in which
Matthews, Keith R
core   +2 more sources

Mutations in human dynamin block an intermediate stage in coated vesicle formation [PDF]

, 1993
The role of human dynamin in receptor-mediated endocytosis was investigated by transient expression of GTP-binding domain mutants in mammalian cells. Using assays which detect intermediates in coated vesicle formation, the dynamin mutants were found to ...
Damke, Hanna, Meyerowitz, Elliot M., Redelmeier, Thomas E., Schmid, Sandra L., Tisdale, Ellen J., van der Bliek, Alexander M.   +5 more
core   +3 more sources