Results 81 to 90 of about 14,134 (199)

Improving the diagnosis of cobalamin and related defects by genomic analysis, plus functional and structural assessment of novel variants

Orphanet Journal of Rare Diseases, 2018
Background Cellular cobalamin defects are a locus and allelic heterogeneous disorder. The gold standard for coming to genetic diagnoses of cobalamin defects has for some time been gene-by-gene Sanger sequencing of individual DNA fragments.
Sandra Brasil, Fátima Leal, Ana Vega, Rosa Navarrete, María Jesús Ecay, Lourdes R. Desviat, Casandra Riera, Natàlia Padilla, Xavier de la Cruz, Mari Luz Couce, Elena Martin-Hernández, Ana Morais, Consuelo Pedrón, Luis Peña-Quintana, Miriam Rigoldi, Norma Specola, Isabel Tavares de Almeida, Inmaculada Vives, Raquel Yahyaoui, Pilar Rodríguez-Pombo, Magdalena Ugarte, Celia Pérez-Cerda, Begoña Merinero, Belén Pérez   +23 more
doaj   +1 more source

Cobalamin, the stomach, and aging [PDF]

The American Journal of Clinical Nutrition, 1997
Low cobalamin concentrations are common in the elderly. Although only a minority of such persons display clinically obvious symptoms or signs, metabolic data clearly show cellular deficiency of cobalamin in most cases. The evidence suggests that this is not a normal physiologic expression of the aging process. Rather, the elderly seem at increased risk
openaire   +3 more sources

Brewer's spent grain: Unveiling innovative applications in the food and packaging industry

Comprehensive Reviews in Food Science and Food Safety, Volume 24, Issue 3, May 2025.
Abstract Brewer's spent grain, a byproduct of beer brewing, is often discarded as waste, leading to environmental concerns. However, the growing interest in sustainability and the circular bioeconomy has prompted research into its use in food and packaging industries.
Pramod Aradwad, Sharvari Raut, Ahmed Abdelfattah, Cornelia Rauh, Barbara Sturm   +4 more
wiley   +1 more source

Expression of the cobalamin transporters cubam and MRP1 in the canine ileum-Upregulation in chronic inflammatory enteropathy.

PLoS ONE
Chronic inflammatory enteropathy (CIE) in dogs, a spontaneous model of human inflammatory bowel disease (IBD), is associated with a high rate of cobalamin deficiency.
Stefanie Kather, Johannes Kacza, Helga Pfannkuche, Denny Böttcher, Chi-Hsuan Sung, Joerg M Steiner, Gotthold Gäbel, Franziska Dengler, Romy M Heilmann   +8 more
doaj   +1 more source

Regulation of Hematopoiesis and Methionine Homeostasis by mTORC1 Inhibitor NPRL2

Cell Reports, 2015
Nitrogen permease regulator-like 2 (NPRL2) is a component of a conserved complex that inhibits mTORC1 (mammalian Target Of Rapamycin Complex 1) in response to amino acid insufficiency. Here, we show that NPRL2 is required for mouse viability and that its
Paul A. Dutchak, Sunil Laxman, Sandi Jo Estill, Chensu Wang, Yun Wang, Yiguang Wang, Gamze B. Bulut, Jinming Gao, Lily J. Huang, Benjamin P. Tu   +9 more
doaj   +1 more source

Single Enema Fecal Microbiota Transplantation in Cats With Chronic Enteropathy

Journal of Veterinary Internal Medicine, Volume 39, Issue 3, May/June 2025.
ABSTRACT Background Chronic enteropathies (CE) are common in cats, and alterations of the intestinal microbiota might be involved in the pathogenesis. Hypothesis/Objectives To evaluate the efficacy of a single enema fecal microbiota transplantation (FMT) in improving intestinal dysbiosis and clinical scores in cats with CE.
Dimitra A. Karra, Jan S. Suchodolski, Shelley J. Newman, Evgenia Flouraki, Jonathan A. Lidbury, Joerg M. Steiner, Panagiotis G. Xenoulis   +6 more
wiley   +1 more source

Prognostic potential of copper, zinc, copper/zinc ratio, cobalamin, and serum amyloid A in cats with panleukopenia

Journal of Veterinary Internal Medicine
Background Copper (Cu), zinc (Zn), and the copper/zinc ratio (Cu/Zn), which have been studied in gastrointestinal disorders of humans, may facilitate disease prognosis. Objective Evaluate the predictive potential of Cu, Zn, cobalamin, and serum amyloid A
Kerim Emre Yanar, Sümeyye Baysal, Nergis Ulaş, Mustafa Sinan Aktaş, Mehmet Özkan Timurkan, Hakan Aydın   +5 more
doaj   +1 more source

Cerebrovascular Involvement in Systemic Sclerosis

ACR Open Rheumatology, Volume 7, Issue 4, April 2025.
Systemic sclerosis (SSc) is a chronic autoimmune rheumatic disease characterized by vascular damage, immune system dysregulation and fibrosis. The hallmark features include microvascular alterations and progressive tissue fibrosis, affecting skin, internal organs as well central and peripheral nervous system, adding to the disease's complexity and ...
Maurizio Cutolo, Tamara Vojinovic, Sabrina Paolino, Rosanna Campitiello, Vanessa Smith   +4 more
wiley   +1 more source

Genetic Insights Into Hyaline Fibromatosis Syndrome: A Case Report of an ANTXR2 Mutation Featuring a Rare Variant c.697+1G>A

Clinical Case Reports, Volume 13, Issue 4, April 2025.
ABSTRACT Hyaline fibromatosis syndrome (HFS) is a rare genetic disorder encompassing juvenile hyaline fibromatosis (JHF) and infantile systemic hyalinosis (ISH), caused by mutations in the anthrax toxin receptor 2 gene (ANTXR2). This condition leads to the accumulation of hyaline plaques in the skin and organs, resulting in symptoms such as skin ...
Shabnam Hajiani Ghotbabadi, Reza Shiari, Shayan Yousufzai, Simin Sharifi   +3 more
wiley   +1 more source

Lettuce fortification through vitamin B12‐producing bacteria – proof of concept study

Journal of the Science of Food and Agriculture, Volume 105, Issue 6, Page 3343-3354, April 2025.
Abstract BACKGROUND Vitamin B12 (cobalamin) can be produced de novo only by certain bacteria and archaea. It plays a crucial role in the health of animals and humans, which obtain it only through diet, mainly from animal products. This study aimed to identify endophytic bacterial strains capable of synthesizing vitamin B12 and enriching edible plants ...
Sara Pipponzi, Stefanie Primisser, Livio Antonielli, Emilio Stefani, Stephane Compant, Angela Sessitsch, Tanja Kostic   +6 more
wiley   +1 more source