Results 61 to 70 of about 19,626,692 (182)

Changes in markers of cobalamin status after cessation of oral B-vitamin supplements in elderly people with mild cobalamin deficiency

, 2008
Mildly cobalamin-deficient elderly were supplemented with 1000 g cobalamin (group C, n=34), 1000 g cobalamin with 400 g folic acid (group CF, n=31) or a placebo (n=30) for 6 months.
van Staveren, W A, Ueland, P.M., Blom, H J, Hiddink, G.J., Ueland, P M, Hoefnagels, W H L, Groot, C.P.G.M., de, Hoefnagels, W.H.L., Hiddink, G J, Eussen, S J P M, Schneede, J., Schneede, Jörn,, Blom, H.J., de Groot, L C P G M, Eussen, S.J.P.M., Staveren, W.A., van   +15 more
core   +1 more source

A Cobalamin‐Dependent Radical SAM Enzyme Catalyzes the Unique C(α)‐Methylation of Glutamine in Methyl‐Coenzyme M Reductase

, 2022
Methyl‐coenzyme M reductase, which is responsible for the production of the greenhouse gas methane during biological methane formation, carries several unique posttranslational amino acid modifications, including a 2‐(S)‐methylglutamine.
Thorsten Friedrich, Christoph Loenarz, Gagsteiger, Jana, Jahn, Sören, Andexer, Jennifer N., Lukas Gericke, Loenarz, Christoph, Sören Jahn, Gericke, Lukas, Lorenz Heidinger, Gunhild Layer, Jennifer N. Andexer, Jana Gagsteiger, Heidinger, Lorenz, Layer, Gunhild, Friedrich, Thorsten, Andexer, Jennifer, Lönarz, Christoph   +17 more
core   +1 more source

Generation of a transgenic pluripotent stem cell line expressing MMACHC protein harbouring the renal 2 thrombotic microangiopapathy-causing mutation (p.Q27R)

Stem Cell Research
Mutations in the MMACHC (metabolism of cobalamin associated C) gene are associated with cobalamin C disorder and have been reported in infants with renal thrombotic microangiopaopathy (TMA).
Zhiqi Zhou, Xiao’e Zhang, Cuilan Hou, Ying Wu   +3 more
doaj   +1 more source

Synthesis of a “Base‐On” Yellow Corrinoid From Vitamin B12

Helvetica Chimica Acta, EarlyView.
A rare “base‐on” yellow corrinoid is obtained from vitamin B12 in a concise semi‐synthesis. Structural and spectroscopic characterization identifies 5,6‐dihydroxyaquacobalamin, in which interruption of the corrin π‐system coexists with dimethylbenzimidazole coordination to cobalt(III), providing new insight into the structure and electronic properties ...
Lucas Prieto, Christopher Brenig, Felix Zelder   +2 more
wiley   +1 more source

Vitamin B12 deficiency in an infant secondary to nutritional deficiency and an inadequate maternal diet

JPGN Reports, EarlyView.
ABSTRACT Vitamin B12 (cobalamin, Cbl) is an essential micronutrient for DNA synthesis and neurological development. Its deficiency in infants, although infrequent in developed countries, can cause megaloblastic anemia, psychomotor delay, and neurological damage that may become irreversible if not treated early.
Sandra Sala‐Lluch, Nerea Mesas‐Vila, Susana Ferrando‐Monleón, Ana Barrés‐Fernández, Cristina Villar‐Vera, José Vicente Arcos‐Machancoses   +5 more
wiley   +1 more source

Late-onset cblC deficiency around puberty: a retrospective study of the clinical characteristics, diagnosis, and treatment

Orphanet Journal of Rare Diseases, 2022
Background cblC deficiency is the most common type of methylmalonic aciduria in China. Late-onset patients present with various non-specific symptoms and are usually misdiagnosed.
Zhehui Chen, Hui Dong, Yupeng Liu, Ruxuan He, Jinqing Song, Ying Jin, Mengqiu Li, Yi Liu, Xueqin Liu, Hui Yan, Jianguang Qi, Fang Wang, Huijie Xiao, Hong Zheng, Lulu Kang, Dongxiao Li, Yao Zhang, Yanling Yang   +17 more
doaj   +1 more source

More than just anemia: Uncovering celiac disease beneath the surface: A case report

JPGN Reports, EarlyView.
Abstract Celiac disease (CD) is an immune‐mediated disorder triggered by gluten in genetically susceptible individuals. Although iron deficiency anemia is a common presentation, other micronutrient deficiencies may occur. We describe a 3.5‐year‐old female whose initial presentation of CD was severe, asymptomatic normocytic anemia secondary to copper ...
Evan Greenhall, Bri Best, David F. Carpenteri, Paula Prieto‐Tizzard   +3 more
wiley   +1 more source

Macronutrient and micronutrient profiles of meat types: insights into human health and diet

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Despite considerable advances in global health and nutrition, emerging challenges such as population growth, climate change, and limited natural resources continue to threaten food security. Meat remains an essential component of the human diet, supplying high‐quality proteins, essential amino acids, lipids, vitamins, and minerals necessary ...
Özgül Anitaş, Serap Göncü, Fatma Hepsağ, Nazan Koluman, Yesim Ozogul   +4 more
wiley   +1 more source

Noncompaction of the Ventricular Myocardium and Hydrops Fetalis in Cobalamin C Disease [PDF]

, 2012
Cobalamin C disease (cblC), a form of combined methylmalonic acidemia and hyperhomocysteinemia caused by mutations in the MMACHC gene, may be the most common inborn error of intracellular cobalamin metabolism. The clinical manifestations of cblC disease are diverse and range from intrauterine growth retardation to adult onset neurological disease.
Pranoot, Tanpaiboon, Jennifer L, Sloan, Patrick F, Callahan, Dorothea, McAreavey, P Suzanne, Hart, Uta, Lichter-Konecki, Dina, Zand, Charles P, Venditti   +7 more
openaire   +2 more sources

Overview of the re‐evaluation of trace elements as nutritional feed additives in the European Union: characterization, safety, and efficacy

Journal of the Science of Food and Agriculture, EarlyView.
Abstract The re‐evaluation of feed additives in the European Union was outlined in the Regulation (EC) No 1831/2003. The primary objectives were to ensure safety and verify efficacy, as well as to update authorizations and phase out unsafe additives or those in which the industry expressed no interest.
Gloria López‐Gálvez, Maria de Lourdes Bastos, Francesco Cubadda, Mikolaj A Gralak, Christer Hogstrand, Matteo L Innocenti, Joop de Knecht, Marta López‐Alonso, Alberto Mantovani, Alena Pechová, Fernando Ramos, Jürgen Gropp   +11 more
wiley   +1 more source