Results 131 to 140 of about 465,921 (178)

Performance of the Serum Cobalamin Assay for Diagnosis of Cobalamin Deficiency

American Journal of the Medical Sciences, 1994
The authors' objective, with this study, was to determine the use in routine clinical practice of the cobalamin serum assay in evaluating patients suspected of having cobalamin deficiency. The design was a prospective observational study of a diagnostic test compared with a criterion gold standard.
Douglas C McCrory, David B Matchar, David S Millington   +2 more
exaly   +3 more sources

Cobalamin Deficiency

2011
Cobalamin (Cbl, vitamin B12) consists of a corrinoid structure with cobalt in the centre of the molecule. Neither humans nor animals are able to synthesize this vitamin. Foods of animal source are the only natural source of cobalamin in human diet.
Wolfgang, Herrmann, Rima, Obeid
openaire   +2 more sources

MRI findings in cobalamin deficiency

Journal of Clinical Neuroscience, 2003
A 55 year old male presented 2 years after a jejuno-iliectomy with weakness of all limbs, paraesthesiae, and difficulty in walking. Clinical examination revealed loss of posterior column sensations. Investigations were suggestive of a deficiency of vitamin B12 and folate.
Kavita K, Krishna, Abou-Sharbin Maher, Arafat, Nasli Rustom, Ichaporia, M M, Jain   +3 more
openaire   +2 more sources

Subclinical cobalamin deficiency

Current Opinion in Gastroenterology, 2012
This review focuses on recent developments and controversies in the diagnosis, consequences, and management of subclinical cobalamin deficiency (SCCD), which affects many elderly persons.Diagnosis of SCCD depends exclusively on biochemical tests whose individual limitations suggest that combinations of tests are needed, especially in epidemiologic ...
openaire   +2 more sources

How to diagnose cobalamin deficiency

Scandinavian Journal of Clinical and Laboratory Investigation, 1994
Cobalamin deficiency must be suspected in all patients with unexplained neuropsychiatric symptoms or unexplained anemia. Special attention should be paid to patients at risk of developing cobalamin deficiency such as elderly people, vegetarians, HIV-infected patients, patients with gastrointestinal diseases and patients with autoimmunity or a family ...
E, Nexø, M, Hansen, K, Rasmussen, A, Lindgren, R, Gräsbeck   +4 more
openaire   +2 more sources

Leukoencephalopathy associated with cobalamin deficiency

Neurology, 1996
Patients with cobalamin deficiency may experience cognitive impairment or neuropsychiatric symptoms. Although abnormalities of central myelin are the presumed cause of these manifestations, there is a paucity of reports of white matter lesions as shown on neuroimaging studies, and the effects of cobalamin replacement on these lesions are not known.
A, Chatterjee, R, Yapundich, C A, Palmer, D C, Marson, G W, Mitchell   +4 more
openaire   +2 more sources

Plasma cobalamin‐binding and serum cobalamin in patients with folate deficiency

Scandinavian Journal of Haematology, 1985
Plasma unsaturated R‐binder and transcobalamin 2 (TC 2) levels were measured in 62 patients with folate deficiency and compared with 80 control subjects and 52 patients with pernicious anaemia. An increase in unsaturated R‐binder concentration was found in the majority of patients with folate deficiency and with PA.
M J, Lewis, D W, Dawson
openaire   +2 more sources

Cobalamin-binding proteins in normal and cobalamin-deficient older subjects

Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 2003
Background: The causes of cobalamin (vitamin B 12 ) deficiency in older people are only partly understood. We investigated the role of the cobalamin-binding proteins and tested the hypothesis that low saturated transcobalamin concentration is an early marker of cobalamin deficiency.
Asselt, D.Z.B. van, Thomas, C.M.G., Segers, M.F.G., Blom, H.J., Wevers, R.A., Hoefnagels, W.H.L.   +5 more
openaire   +3 more sources

Changes in Serum Levels of Cobalamin and Cobalamin Analogues in Folate Deficiency

Scandinavian Journal of Haematology, 1981
The recent introduction of radioassays for ‘true’ cobalamin, as opposed to cobalamin and its analogues, has resulted in significantly lower levels of cobalamin being found in patients with folate deficiency.In study of 81 patients, cobalamin analogue levels were found to increase and cobalamin to decrease as red cell folates decreased.
K, Sheppard, D, Ryrie
openaire   +2 more sources

Peripheral neuropathy due to cobalamin deficiency

Current Treatment Options in Neurology, 2002
Vitamin B12, or cobalamin (Cbl), deficiency can produce a number of neurologic complications, including myelopathy, peripheral neuropathy, optic neuropathy, and dementia. The myelopathy, combined systems disease, is probably the most well known manifestation, and is usually readily recognized.
David S., Saperstein, Richard J., Barohn
openaire   +2 more sources