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Current Concepts in Cobalamin Deficiency [PDF]
Annual Review of Medicine, 2000 The application of sensitive metabolic tests, such as the deoxyuridine suppression test and measurement of homocysteine and methylmalonic acid, to cobalamin status has identified the entity of mild, preclinical cobalamin deficiency. This state, common in the elderly, responds to cobalamin therapy.
R Carmel, Ralph Carmel
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Effective Treatment of Cobalamin Deficiency With Oral Cobalamin
Blood, 1998Because cobalamin deficiency is routinely treated with parenteral cobalamin, we investigated the efficacy of oral therapy. We randomly assigned 38 newly diagnosed cobalamin deficient patients to receive cyanocobalamin as either 1 mg intramuscularly on days 1, 3, 7, 10, 14, 21, 30, 60, and 90 or 2 mg orally on a daily basis for 120 days.
Sally Stäbler, Stäbler Sally P
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Performance of the Serum Cobalamin Assay for Diagnosis of Cobalamin Deficiency
American Journal of the Medical Sciences, 1994The authors' objective, with this study, was to determine the use in routine clinical practice of the cobalamin serum assay in evaluating patients suspected of having cobalamin deficiency. The design was a prospective observational study of a diagnostic test compared with a criterion gold standard.
Douglas Mccrory +2 more
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The retention of cobalamin by the liver in the cobalamin-deficient rat [PDF]
Clinical Science, 1985 1. The effect of cobalamin deficiency on whole body cobalamin content and its turnover was examined in the rat. Quantitative and qualitative changes in hepatic cobalamin were also followed and the effect of deficiency on the turnover of this cobalamin was determined in the isolated perfused liver. 2.
Owens, J.A. +2 more
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Cobalamin-binding proteins in normal and cobalamin-deficient older subjects [PDF]
Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 2003 Background: The causes of cobalamin (vitamin B 12 ) deficiency in older people are only partly understood. We investigated the role of the cobalamin-binding proteins and tested the hypothesis that low saturated transcobalamin concentration is an early marker of cobalamin deficiency.
Asselt, D.Z.B. van +5 more
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New insights into the pathophysiology of cobalamin deficiency [PDF]
Trends in Molecular Medicine, 2006 Cobalamin-deficient (Cbl-D) central neuropathy in the rat is associated with a locally increased expression of neurotoxic tumour necrosis factor-alpha (TNF-alpha) and a locally decreased expression of neurotrophic epidermal growth factor (EGF). These recent findings suggest that cobalamin oppositely regulates the expression of TNF-alpha and EGF, and ...
G. Scalabrino, M. Peracchi
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Involuntary Movements in Cobalamin Deficiency
Klinische Pädiatrie, 2023Abstract Objective Neurologic problems are frequently described in infants with nutritional vitamin B12 (cobalamin) deficiency.Major neurologic consequences of infantile cobalamin deficiency include delays or regression in neurodevelopment and the occurrence of involuntary movements
Hamit, Özyürek +3 more
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2011
Cobalamin (Cbl, vitamin B12) consists of a corrinoid structure with cobalt in the centre of the molecule. Neither humans nor animals are able to synthesize this vitamin. Foods of animal source are the only natural source of cobalamin in human diet.
Wolfgang, Herrmann, Rima, Obeid
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Cobalamin (Cbl, vitamin B12) consists of a corrinoid structure with cobalt in the centre of the molecule. Neither humans nor animals are able to synthesize this vitamin. Foods of animal source are the only natural source of cobalamin in human diet.
Wolfgang, Herrmann, Rima, Obeid
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Subclinical cobalamin deficiency
Current Opinion in Gastroenterology, 2012This review focuses on recent developments and controversies in the diagnosis, consequences, and management of subclinical cobalamin deficiency (SCCD), which affects many elderly persons.Diagnosis of SCCD depends exclusively on biochemical tests whose individual limitations suggest that combinations of tests are needed, especially in epidemiologic ...
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