Production, Purification, and Applications of a Potential Theranostic Pair: Cobalt-55 and Cobalt-58m [PDF]
Diagnostics, 2021 The emerging success of [68Ga/177Lu]Ga/Lu-DOTATATE as a theranostic pair has spurred interest in other isotopes as potential theranostic combinations. Here, we review cobalt-55 and cobalt-58m as a potential theranostic pair. Radionuclidically pure cobalt-
Kendall E. Barrett +4 more
doaj +5 more sources
PET Imaging of the Neurotensin Targeting Peptide NOTA-NT-20.3 Using Cobalt-55, Copper-64 and Gallium-68 [PDF]
Pharmaceutics, 2022 Introduction: Neurotensin receptor 1 (NTSR1) is an emerging target for imaging and therapy of many types of cancer. Nuclear imaging of NTSR1 allows for noninvasive assessment of the receptor levels of NTSR1 on the primary tumor, as well as potential ...
Hailey A. Houson +5 more
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Preclinical Evaluation of the Copper-64 Labeled GRPR-Antagonist RM26 in Comparison with the Cobalt-55 Labeled Counterpart for PET-Imaging of Prostate Cancer [PDF]
Molecules, 2020 Gastrin-releasing peptide receptor (GRPR) is overexpressed in the majority of prostate cancers. This study aimed to investigate the potential of 64Cu (radionuclide for late time-point PET-imaging) for imaging of GRPR expression using NOTA-PEG2-RM26 and ...
Christina Baun +7 more
doaj +8 more sources
Theranostic cobalt-55/58m for neurotensin receptor-mediated radiotherapy in vivo: A pilot study with dosimetry. [PDF]
Nucl Med Biol, 2023 Neurotensin receptor 1 (NTSR1) can stimulate tumor proliferation through neurotensin (NTS) activation and are overexpressed by a variety of cancers. The high binding affinity of NTS/NTSR1 makes radiolabeled NTS derivatives interesting for cancer diagnosis and staging.
Lin W +9 more
europepmc +3 more sources
Separation of cyclotron-produced cobalt-55/58m from iron targets using cation exchange chromatography with non-aqueous solvents and extraction chromatography. [PDF]
Appl Radiat Isot, 2023 Cobalt-55 and -58m form a theranostic pair that has relevant properties for cancer research. We report a cation exchange chromatography/extraction chromatography method that separates cyclotron-produced 55/58mCo from 54/57Fe in 85% Co and achieves [55Co]Co-NOTA and -DOTA AMA 89 ± 48 and 35 ± 7 MBq/nmol (EOB), respectively.
Lin W +6 more
europepmc +3 more sources
Radiolabeling Diaminosarcophagine with Cyclotron-Produced Cobalt-55 and [<sup>55</sup>Co]Co-NT-Sarcage as a Proof of Concept in a Murine Xenograft Model. [PDF]
Bioconjug ChemCobalt-sarcophagine complexes exhibit high kinetic inertness under various stringent conditions, but there is limited literature on radiolabeling and in vivo positron emission tomography (PET) imaging using no carrier added 55Co. To fill this gap, this study first investigates the radiolabeling of DiAmSar (DSar) with 55Co, followed by stability ...
Lin W +7 more
europepmc +3 more sources
Radiocobalt theranostic applications: current landscape, challenges, and future directions [PDF]
Frontiers in Nuclear MedicineRadiocobalt-based theranostics has emerged as a promising platform in nuclear medicine that offers dual capabilities for both diagnostic imaging and targeted radionuclide therapy. 55Co (t1/2 = 17.53 h, β+ = 77%, Eγ = 931.1 keV, Iγ = 75%) and 58mCo (t1/2 =
Alexis M. Sanwick, Ivis F. Chaple
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Cobalt-55 positron emission tomography in traumatic brain injury: a pilot study. [PDF]
Journal of Neurology, Neurosurgery & Psychiatry, 1996 Traumatic brain injury is usually assessed with the Glasgow coma scale (GCS), CT, or MRI. After such injury, the injured brain tissue is characterised by calcium mediated neuronal damage and inflammation. Positron emission tomography with the isotope cobalt-55 (Co-PET) as a calcium tracer enables imaging of affected tissue in traumatic brain injury ...
Jansen, HML +8 more
openaire +5 more sources
Molecules, 2022 Nowadays, cobalt isotopes 55Co, 57Co, and 58mCo are considered to be promising radionuclides in nuclear medicine, with 55Co receiving the most attention as an isotope for diagnostics by positron emission tomography. One of the current research directions
Andrey G. Kazakov +7 more
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مجله دانشکده دندانپزشکی اصفهان, 2022 Metals are widely used in direct and indirect restorative materials, both in prosthetics and orthodontics. The biocompatibility of these metals depends on their chemical nature, the number of ions released, and the period of contact ...
Amir Adib +3 more
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