Results 121 to 130 of about 13,397 (223)

Progress in Natural Products Target Discovery Technology

MedComm, Volume 7, Issue 6, June 2026.
Here, we provide a comprehensive overview of current technologies and recent advancements in therapeutic target discovery for natural products. By systematically synthesizing the principles, methodologies, and practical applications of existing experimental and computational strategies, this work provides a more actionable reference framework for ...
Qiyuan Pan, Xiao Yuan, Jinmei Jin, Xin Luan, Cheng Luo, Hongzhuan Chen, Weidong Zhang, Hao Zhang   +7 more
wiley   +1 more source

Health Care Costs and Use of Patients Prescribed Four Different Obesity Medications

Obesity, Volume 34, Issue 6, Page 1331-1342, June 2026.
ABSTRACT Objective This study compared changes in health care costs and use across cohorts initiating four obesity medications (OMs). Methods Commercial insurance claims were used to identify new initiators of phentermine (n = 136,788), phentermine‐topiramate‐ER (n = 13,888), naltrexone‐bupropion‐SR (n = 28,712), or liraglutide (n = 49,266) for obesity.
Kristina H. Lewis, Fang Zhang, Robert F. LeCates, Stephanie Argetsinger, Stefanie Albert, Geetha S. Iyer, John G. Connolly, James F. Wharam, David E. Arterburn, Dennis Ross‐Degnan, Sengwee Toh   +10 more
wiley   +1 more source

Development and Performance of the ANDES/COBRA-III Coupled System in Hexagonal-Z Geometry [PDF]

, 2009
In this paper, the extension of the nodal diffusion code ANDES, based on the ACMFD method, to hexagonal geometry is presented, as well as its coupling with the thermal-hydraulic (TH) code COBRA-IIIc/MIT-2 for such hexagonal problems.
Aragonés Beltrán, José María, Jiménez Escalante, Javier, García Herranz, Nuria, Lozano Montero, Juan Andrés   +3 more
core  

Primary structure of a cytotoxin-like basic protein from Naja naja naja (Indian Cobra) venom

, 1995
The complete amino acid sequence of a cytotoxin-like basic protein (CLBP) from the venom of Naja naja naja (Indian Cobra) was determined by manual degradation using a 4-dimethylaminoazobenzene-4'-isothiocyanate double-coupling method.
Gowda, TV, Babu, AS, Puri, KD, Babu, A. S., Veerabasappa Gowda, T., A.S. BABU, Puri, K. D., K.D. PURI, T.V. GOWDA   +8 more
core   +1 more source

Cognition Assessment in Virtual Reality (CAVIR)—Spanish Version: Validation of a Novel Virtual Reality Test for Daily‐Life Cognitive Skills in Bipolar Disorder

Bipolar Disorders, Volume 28, Issue 4, June 2026.
ABSTRACT Objectives There is a need for ecologically valid measures of real‐life cognitive functioning. We investigated: (I) the sensitivity of the Cognition Assessment in Virtual Reality (CAVIR) test, which assesses daily‐life cognitive skills in an immersive virtual reality kitchen scenario, to capture cognitive impairments in a Spanish sample of ...
Natalia E. Fares‐Otero, Brisa Solé, Andreas Elleby Jespersen, Natalia Roberto‐Herrero, Sara Martin‐Parra, Ricardo Lopez‐Escribano, Anaid Pérez‐Ramos, Flavia Piazza, Andrea Ruiz‐Muñoz, Cristina Varo, Anders Morrison Lumbye, Eduard Vieta, Anabel Martinez‐Aran, Kamilla Woznica Miskowiak   +13 more
wiley   +1 more source

A Natural LTR Retrotransposon Insertion in the Promoter of GhNAC140‐Dt Boosts Cotton Lint Yield

Plant Biotechnology Journal, Volume 24, Issue 6, Page 4240-4262, June 2026.
ABSTRACT Transposable elements (TEs) are fundamental drivers of crop evolution and domestication. Whereas the underlying mechanisms of TE‐mediated gene activation remain poorly understood. Lint percentage is an important yield component in cotton. Here, we report a retrotransposon insertion in the promoter of GhNAC140‐Dt, a secondary wall NAC encoding ...
Yujia Yu, Xiaoguang Shang, Haitang Wang, Lijie Zhu, Xu Han, Qingfei He, Weixi Li, Yonglin Tan, Guozhong Zhu, Wangzhen Guo   +9 more
wiley   +1 more source

Digital Disease Ecologies: Encounter, Datafication and the Digital Geographies of One Health

Transactions of the Institute of British Geographers, Volume 51, Issue 2, June 2026.
Short Abstract Through the case of Snake Awareness Rescue Protection App (SARPA), a digital snake translocation and snakebite prevention mobile phone application in Kerala, India, this paper extends recent geographical ‘digital ecologies’ scholarship's concern for the digitisation of more‐than‐human worlds to digital health technology and disease ...
George Kirkham
wiley   +1 more source

Biochemical and biological characterization of the venoms of Naja kaouthia and Naja mandalayensis from Myanmar and neutralization effects of BPI cobra antivenom

Toxicon: X
Snakebite is a neglected public health issue, with many scientific and medical issues to be solved. Cobras are among the most common venomous snakes in Myanmar and are responsible for a considerable number of severe snakebite envenoming.
Mya Nila Win, Khin Than Yee, Kyae Mhon Htwe, Ei Ei Thin, Su Mon Win, Aung Myat Kyaw, Myo Myo Aye, Kyaw Kyaw Khaing, Wai Myat Thwe, Khin Khin Htwe, Aung Zaw   +10 more
doaj   +1 more source

COBRA combination therapy in patients with early rheumatoid arthritis: long-term structural benefits of a brief intervention

, 2002
The Combinatietherapie Bij Reumatoide Artritis (COBRA) trial demonstrated that step-down combination therapy with prednisolone, methotrexate, and sulfasalazine (SSZ) was superior to SSZ monotherapy for suppressing disease activity and radiologic ...
Jacobs, Piet, Verhoeven, Arco C., van der Heijde, Désirée M. F. M., van Denderen, J. Christiaan, Dijkmans, Ben A. C., Westedt, Marie Louise, Peeters, Andre J., van der Linden, Sjef, Boers, Maarten, Boonen, Annelies, Westhovens, Rene, van de Laar, Mart A. F. J., Landewé, Robert B. M., Markusse, Harry M.   +13 more
core   +1 more source

COBRA -- COnfidence score Based on shape Regression Analysis for method-independent quality assessment of object pose estimation from single images

CoRR
We propose a generic procedure for assessing 6D object pose estimates. Our approach relies on the evaluation of discrepancies in the geometry of the observed object, in particular its respective estimated back-projection in 3D, against a putative functional shape representation comprising mixtures of Gaussian Processes, that act as a template.
Sapoutzoglou, Panagiotis, Giapitzakis, Georgios, Floros, Georgios, Terzakis, George, Pateraki, Maria   +4 more
openaire   +2 more sources