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Epigenetic regulation of cocaine intake through dopaminergic control of cholinergic interneurons in male mice. [PDF]
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Emergency Medicine Clinics of North America, 1990
There has been a dramatic rise in the number of adverse medical effects related to cocaine abuse since the widespread introduction of crystallized freebase cocaine or "crack" in the mid-1980s. In particular, cardiovascular and central nervous system toxicity is becoming more widely recognized and requires aggressive medical management to prevent ...
P D, Mueller, N L, Benowitz, K R, Olson
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There has been a dramatic rise in the number of adverse medical effects related to cocaine abuse since the widespread introduction of crystallized freebase cocaine or "crack" in the mid-1980s. In particular, cardiovascular and central nervous system toxicity is becoming more widely recognized and requires aggressive medical management to prevent ...
P D, Mueller, N L, Benowitz, K R, Olson
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Pediatric Annals, 1987
This article discusses cocaine as America's leading illicit drug of abuse. Cocaine pharmacology, metabolism, and methods of administration are related to medical symptoms and complications of use. Reasons for increased use as well as signs suggestive of individual abuse are given, and treatment issues specific to cocaine are discussed.
H C, Mofenson, T R, Caraccio
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This article discusses cocaine as America's leading illicit drug of abuse. Cocaine pharmacology, metabolism, and methods of administration are related to medical symptoms and complications of use. Reasons for increased use as well as signs suggestive of individual abuse are given, and treatment issues specific to cocaine are discussed.
H C, Mofenson, T R, Caraccio
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Cocaine-induced cocaine craving
Psychopharmacology, 1989In nine experienced users of cocaine, we examined the urge to use cocaine or other drugs following a 40 mg dose of intravenous (IV) cocaine with and without oral pretreatment with 2.5 mg bromocriptine. The urge to use cocaine was assessed with a questionnaire constructed to assess both "wanting" and "craving" for cocaine or other drugs. Fifteen minutes
J H, Jaffe +3 more
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Annual Review of Medicine, 1989
Cocaine has been proclaimed the "drug of greatest national public health concern." Recent clinical investigations demonstrate that cocaine causes abuse and withdrawal patterns differing from those of other major abused drugs. These observations converge with preclinical data to suggest that cocaine dependence, rather than being a purely "psychological"
F H, Gawin, E H, Ellinwood
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Cocaine has been proclaimed the "drug of greatest national public health concern." Recent clinical investigations demonstrate that cocaine causes abuse and withdrawal patterns differing from those of other major abused drugs. These observations converge with preclinical data to suggest that cocaine dependence, rather than being a purely "psychological"
F H, Gawin, E H, Ellinwood
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Clinical Toxicology, 1975
Scott's three-solution procedure was examined and should be considered the method of choice for testing pure compounds suspected to be cocaine. Because of false positives for cocaine encountered with mixtures of drugs such as lidocaine and phencyclidine, Scott's procedure should be confirmed using Kodak's Field Kit for alkaloids, or a similar kit.
C L, Winek, T, Eastly
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Scott's three-solution procedure was examined and should be considered the method of choice for testing pure compounds suspected to be cocaine. Because of false positives for cocaine encountered with mixtures of drugs such as lidocaine and phencyclidine, Scott's procedure should be confirmed using Kodak's Field Kit for alkaloids, or a similar kit.
C L, Winek, T, Eastly
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Critical Care Clinics, 2012
Cocaine, a natural alkaloid derived from the coca plant, is one of the most commonly abused illicit drugs. Cocaine is commonly abused by inhalation, nasal insufflation, and intravenous injection, resulting in many adverse effects that ensue from local anesthetic, vasoconstrictive, sympathomimetic, psychoactive, and prothrombotic mechanisms. Cocaine can
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Cocaine, a natural alkaloid derived from the coca plant, is one of the most commonly abused illicit drugs. Cocaine is commonly abused by inhalation, nasal insufflation, and intravenous injection, resulting in many adverse effects that ensue from local anesthetic, vasoconstrictive, sympathomimetic, psychoactive, and prothrombotic mechanisms. Cocaine can
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Postgraduate Medicine, 1989
Cocaine intoxication can be manifested by a multitude of chief presenting complaints. Although cardiovascular and central nervous system stimulation is common, patients may present with a broad array of symptoms. Thus, whenever the underlying cause of a set of symptoms is unexplained, the primary care physician needs to consider the possibility of ...
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Cocaine intoxication can be manifested by a multitude of chief presenting complaints. Although cardiovascular and central nervous system stimulation is common, patients may present with a broad array of symptoms. Thus, whenever the underlying cause of a set of symptoms is unexplained, the primary care physician needs to consider the possibility of ...
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Annals of Internal Medicine, 1993
To discuss the forms of cocaine that are available and their methods of administration and to review the medical complications of cocaine abuse.Pertinent articles were identified through a MEDLINE search of the English-language literature from 1986 to 1992 and through a manual search of bibliographies of all identified articles.All articles describing ...
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To discuss the forms of cocaine that are available and their methods of administration and to review the medical complications of cocaine abuse.Pertinent articles were identified through a MEDLINE search of the English-language literature from 1986 to 1992 and through a manual search of bibliographies of all identified articles.All articles describing ...
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