Results 181 to 190 of about 50,225 (239)

Ototoxicity in Cancer Therapies

open access: yes
Oral Diseases, EarlyView.
Sady Selaimen da Costa   +2 more
wiley   +1 more source

Type 2 Diabetes Mellitus and Hearing Loss: A Prisma Systematic Review and Meta‐Analysis

open access: yesOtolaryngology–Head and Neck Surgery, Volume 173, Issue 5, Page 1041-1053, November 2025.
Abstract Objective To conduct a systematic review and meta‐analysis to assess the association between type 2 diabetes and hearing loss. Data Sources Search conducted in PubMed and Scopus databases for articles published between January 2019 and April 2024.
Miguel Caballero‐Borrego   +1 more
wiley   +1 more source

Transtympanic Injection of Antioxidant‐Eluting Microparticles for Otoprotection From Cisplatin Toxicity in a Mouse Model

open access: yesOtolaryngology–Head and Neck Surgery, Volume 173, Issue 5, Page 1228-1235, November 2025.
Abstract Objective Cisplatin is a chemotherapeutic agent with the undesirable side effect of ototoxicity. Transtympanic injections of antioxidant formulations may provide local otoprotection. We tested a novel antioxidant‐eluting microparticle for its otoprotective capability from systemic cisplatin as measured by cochlear electrophysiology.
Eric Michael Smith   +3 more
wiley   +1 more source

Severe Hearing Loss in Children With Central Nervous System Tumors: A Population‐Based Cancer in Young People in Canada (CYP‐C) Report

open access: yesPediatric Blood &Cancer, Volume 72, Issue 11, November 2025.
ABSTRACT Purpose Children with central nervous system (CNS) tumors are prone to treatment‐related hearing loss (HL) and subsequent functional impairment. This study reports a dedicated population‐based analysis of CNS tumor‐specific rates and predictors of early severe HL.
Hallie Coltin   +13 more
wiley   +1 more source

Detecting Convergence of Amino Acid Physicochemical Properties Underlying the Organismal Adaptive Convergent Evolution

open access: yesMolecular Ecology Resources, Volume 25, Issue 8, November 2025.
ABSTRACT Many studies have proposed various comparative genomic methods to probe the molecular basis for adaptive functional convergence between species, conventionally by detecting the convergence of amino acid states between orthologous protein sequences of these species or lineages.
Shanshan Chen, Zhengting Zou
wiley   +1 more source

Generation and Auditory Phenotypic Characterization of Prps1 p.Ala87Thr Mouse Knock‐In Model for Human DFNX1 Deafness

open access: yesClinical Genetics, Volume 108, Issue 5, Page 566-575, November 2025.
Our mouse model with a c.259G>A transition in PRPS1 showed a significant decrease in the number of hair cells and SGN counts at 48 weeks of age and a reduction in Prps1 enzymatic activity in the KI mouse. This model will serve as a valuable tool for developing therapeutic strategies.
Denise Yan   +6 more
wiley   +1 more source

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