Results 181 to 190 of about 67,013 (327)

Exploring AAV‐Mediated Gene Therapy for Inner Ear Diseases: from Preclinical Success to Clinical Potential

open access: yesAdvanced Science, Volume 12, Issue 33, September 4, 2025.
Current preclinical studies of AAV‐mediated gene therapy explore different strategies based on the characteristics of inner ear diseases. For genetic hearing loss, approaches include the replacement of a “good gene,” removal of a “bad gene,” or direct correction of mutations through base editing.
Fan Wu   +7 more
wiley   +1 more source

Surgical approaches to inner ear therapies. [PDF]

open access: yesCurr Opin Otolaryngol Head Neck Surg
Creber N, Bance M.
europepmc   +1 more source

Frequency-position maps for the chinchilla cochlea [PDF]

open access: bronze, 1977
Donald H. Eldredge   +3 more
openalex   +1 more source

NOX2 Contributes to High‐Frequency Outer Hair Cell Vulnerability in the Cochlea

open access: yesAdvanced Science, Volume 12, Issue 34, September 11, 2025.
This study first identifies NOX2 as a differentially expressed gene related to oxidative damage in the apical and basal turns through single‐cell RNA sequencing. NOX2 gene knockout mitigates OHCs damage caused by neomycin and noise and enhances Nrf2 expression and nuclear translocation.
Meihao Qi   +16 more
wiley   +1 more source

Dexamethasone-eluting cochlear implants reduce inflammation and foreign body response in human and murine cochleae. [PDF]

open access: yesSci Rep
Rahman MT   +20 more
europepmc   +1 more source

Intensity Function of the Cochlea and Cortex [PDF]

open access: bronze, 1971
Richard A. Walloch, Robert E. Brummett
openalex   +1 more source

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